Research output per year
Research output per year
Personal profile
Education
1995 Michigan State University, Ph.D. in Zoology
1989 Hanyang University, M.S. in Genetic Engineering
1986 Seoul National University, B.S. in Agricultural Chemistry
1989 Hanyang University, M.S. in Genetic Engineering
1986 Seoul National University, B.S. in Agricultural Chemistry
Professional Experience
2021.03 - 2023.02 University of Seoul. School of Natural Sciences, Dean
2010.10 - Present University of Seoul. Dept. of Life Science. Professor
2005.10 - 2010.09 University of Seoul. Dept. of Life Science. Associate Professor
2001.09 - 2005.09 University of Seoul. Dept. of Life Science. Assistant Professor
2001.01 - 2001.08 Catholic University Research Professor
1997.03 - 2000.12 Columbia University (New York) Associate Researcher
1995.11 - 1997.02 SUNY at Stony Brook Post-doc
2010.10 - Present University of Seoul. Dept. of Life Science. Professor
2005.10 - 2010.09 University of Seoul. Dept. of Life Science. Associate Professor
2001.09 - 2005.09 University of Seoul. Dept. of Life Science. Assistant Professor
2001.01 - 2001.08 Catholic University Research Professor
1997.03 - 2000.12 Columbia University (New York) Associate Researcher
1995.11 - 1997.02 SUNY at Stony Brook Post-doc
Research Interests
Wnt and Hippo signaling, Mechanisms of cancers and Alzheimer's disease
Major Research Achievements
[2022.08] Tan A, Prasad R, Lee C, and Jho EH*. Past, Present, and Future Perspectives of Transcription Factor EB (TFEB): Mechanisms of regulation and association in disease. Cell Death Differ. 29(8):1433-1449.
[2021.09] Kim S, Song G, Lee T, Kim M, Kwon H, Kim J, Jeong W, Lee U, Na C, Kang S, Kim W, Seong J, and Jho EH*. PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1. Cell Death Differ. 28(9):2555-2570.
[2020.09] Jeong W, Kim S, Lee U, Zhong ZA, Savitsky M, Kwon H, Kim J, Lee T, Cho JW, Williams BO, Katanaev VL, Jho EH*. LDL receptor-related protein LRP6 senses the level of nutrient and regulates Hippo signaling. EMBO Reports 21(9):e50103
- A commentary for this work was presented in “News & Views” in EMBO reports.
- This work has been recommended in Faculty Opinions.
[2020.06] Kim J, Kwon H, Shin YK, Song G, Lee T, Kim Y, Jeong W, Lee U, Zhang X, Nam G, Jeung HC, Kim W, Jho EH*. MAML1/2 promote YAP/TAZ nuclear localization to enhance tumorigenesis. Proc Natl Acad Sci U S A. 117(24):13529-13540.
[2020.05] Kim Y, Kim W, Song Y, Kim JR, Cho K, Moon H, Ro SW, Seo E, Ryu YM, Myung SJ, Jho EH*. Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A. 114:4691-4696.
● Highlighted in Hepatic cell news – April 21, 2017
[2021.09] Kim S, Song G, Lee T, Kim M, Kwon H, Kim J, Jeong W, Lee U, Na C, Kang S, Kim W, Seong J, and Jho EH*. PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1. Cell Death Differ. 28(9):2555-2570.
[2020.09] Jeong W, Kim S, Lee U, Zhong ZA, Savitsky M, Kwon H, Kim J, Lee T, Cho JW, Williams BO, Katanaev VL, Jho EH*. LDL receptor-related protein LRP6 senses the level of nutrient and regulates Hippo signaling. EMBO Reports 21(9):e50103
- A commentary for this work was presented in “News & Views” in EMBO reports.
- This work has been recommended in Faculty Opinions.
[2020.06] Kim J, Kwon H, Shin YK, Song G, Lee T, Kim Y, Jeong W, Lee U, Zhang X, Nam G, Jeung HC, Kim W, Jho EH*. MAML1/2 promote YAP/TAZ nuclear localization to enhance tumorigenesis. Proc Natl Acad Sci U S A. 117(24):13529-13540.
[2020.05] Kim Y, Kim W, Song Y, Kim JR, Cho K, Moon H, Ro SW, Seo E, Ryu YM, Myung SJ, Jho EH*. Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A. 114:4691-4696.
● Highlighted in Hepatic cell news – April 21, 2017
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Retinoic acid-induced protein 14 links mechanical forces to Hippo signaling
Jeong, W., Kwon, H., Park, S. K., Lee, I. S. & Jho, E. H., 10 Sep 2024, In: EMBO Reports. 25, 9, p. 4033-4061 29 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting a chemo-induced adaptive signaling circuit confers therapeutic vulnerabilities in pancreatic cancer
Saito, Y., Xiao, Y., Yao, J., Li, Y., Liu, W., Yuzhalin, A. E., Shyu, Y. M., Li, H., Yuan, X., Li, P., Zhang, Q., Li, Z., Wei, Y., Yin, X., Zhao, J., Kariminia, S. M., Wu, Y. C., Wang, J., Yang, J. & Xia, W. & 11 others, , Dec 2024, In: Cell Discovery. 10, 1, 109.Research output: Contribution to journal › Article › peer-review
Open Access -
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress
Dang, T. T., Kim, M. J., Lee, Y. Y., Le, H. T., Kim, K. H., Nam, S., Hyun, S. H., Kim, H. L., Chung, S. W., Chung, H. T., Jho, E. H., Yoshida, H., Kim, K., Park, C. Y., Lee, M. S. & Back, S. H., 2023, In: Autophagy. 19, 7, p. 2111-2142 32 p.Research output: Contribution to journal › Article › peer-review
Open Access -
O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway
Kim, E., Kang, J. G., Jho, E. H., Yang, W. H. & Cho, J. W., 1 Jun 2022, In: Cancers. 14, 12, 3013.Research output: Contribution to journal › Review article › peer-review
Open Access -
Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease
Tan, A., Prasad, R., Lee, C. & Jho, E. H., Aug 2022, In: Cell Death and Differentiation. 29, 8, p. 1433-1449 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access