Research output per year
Research output per year
Personal profile
Education
1995 Michigan State University, Ph.D. in Zoology
1989 Hanyang University, M.S. in Genetic Engineering
1986 Seoul National University, B.S. in Agricultural Chemistry
1989 Hanyang University, M.S. in Genetic Engineering
1986 Seoul National University, B.S. in Agricultural Chemistry
Professional Experience
2021.03 - 2023.02 University of Seoul. School of Natural Sciences, Dean
2010.10 - Present University of Seoul. Dept. of Life Science. Professor
2005.10 - 2010.09 University of Seoul. Dept. of Life Science. Associate Professor
2001.09 - 2005.09 University of Seoul. Dept. of Life Science. Assistant Professor
2001.01 - 2001.08 Catholic University Research Professor
1997.03 - 2000.12 Columbia University (New York) Associate Researcher
1995.11 - 1997.02 SUNY at Stony Brook Post-doc
2010.10 - Present University of Seoul. Dept. of Life Science. Professor
2005.10 - 2010.09 University of Seoul. Dept. of Life Science. Associate Professor
2001.09 - 2005.09 University of Seoul. Dept. of Life Science. Assistant Professor
2001.01 - 2001.08 Catholic University Research Professor
1997.03 - 2000.12 Columbia University (New York) Associate Researcher
1995.11 - 1997.02 SUNY at Stony Brook Post-doc
Research Interests
Wnt and Hippo signaling, Mechanisms of cancers and Alzheimer's disease
Major Research Achievements
[2022.08] Tan A, Prasad R, Lee C, and Jho EH*. Past, Present, and Future Perspectives of Transcription Factor EB (TFEB): Mechanisms of regulation and association in disease. Cell Death Differ. 29(8):1433-1449.
[2021.09] Kim S, Song G, Lee T, Kim M, Kwon H, Kim J, Jeong W, Lee U, Na C, Kang S, Kim W, Seong J, and Jho EH*. PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1. Cell Death Differ. 28(9):2555-2570.
[2020.09] Jeong W, Kim S, Lee U, Zhong ZA, Savitsky M, Kwon H, Kim J, Lee T, Cho JW, Williams BO, Katanaev VL, Jho EH*. LDL receptor-related protein LRP6 senses the level of nutrient and regulates Hippo signaling. EMBO Reports 21(9):e50103
- A commentary for this work was presented in “News & Views” in EMBO reports.
- This work has been recommended in Faculty Opinions.
[2020.06] Kim J, Kwon H, Shin YK, Song G, Lee T, Kim Y, Jeong W, Lee U, Zhang X, Nam G, Jeung HC, Kim W, Jho EH*. MAML1/2 promote YAP/TAZ nuclear localization to enhance tumorigenesis. Proc Natl Acad Sci U S A. 117(24):13529-13540.
[2020.05] Kim Y, Kim W, Song Y, Kim JR, Cho K, Moon H, Ro SW, Seo E, Ryu YM, Myung SJ, Jho EH*. Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A. 114:4691-4696.
● Highlighted in Hepatic cell news – April 21, 2017
[2021.09] Kim S, Song G, Lee T, Kim M, Kwon H, Kim J, Jeong W, Lee U, Na C, Kang S, Kim W, Seong J, and Jho EH*. PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1. Cell Death Differ. 28(9):2555-2570.
[2020.09] Jeong W, Kim S, Lee U, Zhong ZA, Savitsky M, Kwon H, Kim J, Lee T, Cho JW, Williams BO, Katanaev VL, Jho EH*. LDL receptor-related protein LRP6 senses the level of nutrient and regulates Hippo signaling. EMBO Reports 21(9):e50103
- A commentary for this work was presented in “News & Views” in EMBO reports.
- This work has been recommended in Faculty Opinions.
[2020.06] Kim J, Kwon H, Shin YK, Song G, Lee T, Kim Y, Jeong W, Lee U, Zhang X, Nam G, Jeung HC, Kim W, Jho EH*. MAML1/2 promote YAP/TAZ nuclear localization to enhance tumorigenesis. Proc Natl Acad Sci U S A. 117(24):13529-13540.
[2020.05] Kim Y, Kim W, Song Y, Kim JR, Cho K, Moon H, Ro SW, Seo E, Ryu YM, Myung SJ, Jho EH*. Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A. 114:4691-4696.
● Highlighted in Hepatic cell news – April 21, 2017
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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DKK1 Suppresses Hippo Signaling via PIP3-OGT-LRP6 O-GlcNAcylation in Hepatocellular Carcinoma
Lee, U., Eun, J. W., Kim, T., Shim, H., Choi, Y., Jung, H., Mo, J., Kim, S. S., Baek, G. O., Yoon, M. G., Lee, H., Lee, W., Kim, W., Kim, J., Yi, E. C., Kim, S. U., Cheong, J. Y. & Jho, E. H., 2026, In: Cancer Communications. 46, p. 22 1 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
Tankyrase-1-mediated PARsylation directs TFEB partner switching to regulate selective Wnt target gene expression
Song, G., Park, C. & Jho, E. H., Mar 2026, In: Molecules and Cells. 49, 3, 100313.Research output: Contribution to journal › Article › peer-review
Open Access -
The emerging role of the Hippo signaling pathway in interorgan crosstalk
Song, G., Lee, C. & Jho, E. H., 2026, (Accepted/In press) In: FEBS Journal.Research output: Contribution to journal › Review article › peer-review
Open Access -
Author Correction: SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models (EMBO Molecular Medicine, (2021), 13, 4, (e13076), 10.15252/emmm.202013076)
Kwon, O. C., Song, J. J., Yang, Y., Kim, S. H., Kim, J. Y., Seok, M. J., Hwang, I., Yu, J. W., Karmacharya, J., Maeng, H. J., Kim, J., Jho, E. H., Ko, S. Y., Son, H., Chang, M. Y. & Lee, S. H., 11 Sep 2025, In: EMBO Molecular Medicine. 17, 9, p. 2525-2529 5 p.Research output: Contribution to journal › Comment/debate
Open Access -
Retinoic acid-induced protein 14 links mechanical forces to Hippo signaling
Jeong, W., Kwon, H., Park, S. K., Lee, I. S. & Jho, E. H., 10 Sep 2024, In: EMBO Reports. 25, 9, p. 4033-4061 29 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations