Research output per year
Research output per year
Personal profile
Education
2014 Friedrich-Alexander-University Erlangen-Nürnberg, Ph.D. in Molecular Virology and Cancer Biology
2008 Ewha Womans University, M.S. in Cancer Biology
2006 Ewha Womans University, B.S. in Life Sciences
2008 Ewha Womans University, M.S. in Cancer Biology
2006 Ewha Womans University, B.S. in Life Sciences
Professional Experience
2022. 03 - present: Department of Life Science, University of Seoul, Assistant Professor
2021. 02 - 2022. 02: Institute of Molecular Virology, Ulm University, Project Leader
2020. 07 - 2020. 12: Department of Microbiology, Cleveland Clinic Florida, Research Assistant Professor
2018. 05 –2020. 06: Department of Microbiology, The University of Chicago, Postdoctoral Scholar
2016. 10 – 2018. 04: Universitätsklinikum Erlangen, Junior Group Leader
2014 .03 – 2016. 09: Universitätsklinikum Erlangen, Postdoctoral Fellow
2021. 02 - 2022. 02: Institute of Molecular Virology, Ulm University, Project Leader
2020. 07 - 2020. 12: Department of Microbiology, Cleveland Clinic Florida, Research Assistant Professor
2018. 05 –2020. 06: Department of Microbiology, The University of Chicago, Postdoctoral Scholar
2016. 10 – 2018. 04: Universitätsklinikum Erlangen, Junior Group Leader
2014 .03 – 2016. 09: Universitätsklinikum Erlangen, Postdoctoral Fellow
Research Interests
Viral Immunology, Molecular Virology, Exosome Biology, Host-Virus Interactions
Major Research Achievements
[2022.03] Lee JH., Ostalecki C., Oberstein T., Schierer S., Zinser E., Eberhardt M., Blume K., Plosnita B., Stich L., Bruns H., Coras R., Vera-Gonzales J., Maler M., Baur AS. Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus. EBioMedicine, 77:103903.
[2021.03] Liu G.*, Lee JH.*, Parker ZM., Acharya D., Chiang J., van Ghent M., Chiang J., Riedl W., Davis ME., Wies E., Chiang C., Gack MU. ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity. Nature Microbiology, 6(4):467-478. (*Co-first authorship)
[2019. 10] Riedl W., Acharya D., Lee JH., Liu G.,Serman T., Chiang C., Chan YK., Diamond MS., Gack MU. Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity. Cell Host & Microbe, 26(4):493-503. [2017. 05] Lee JH.*, Ostalecki C.*, Wittki S., Dindorf J., Collenburg L., Schierer S., Simon B., Schliep S., Kremmer E., Schuler G., Baur AS. Multi-Epitope Tissue Analysis Reveals SPPL3-mediated ADAM10 Activation as a Key Step in the Transformation of Melanocytes. Science Signaling, 10, 470. (*Co-first authorship)
[2013. 02] Lee JH., Wittki S., Bräu T., Dreyer F.S., Krätzel K., Dindorf J., Johnston I.C., Gross S., Kremmer E., Zeidler R., Schlötzer-Schrehardt U., Lichtenheld M., Saksela K., Harrer T., Schuler G., Federico M., Baur AS. (2013) HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases. Molecular Cell, 49(4):668-79.
[2021.03] Liu G.*, Lee JH.*, Parker ZM., Acharya D., Chiang J., van Ghent M., Chiang J., Riedl W., Davis ME., Wies E., Chiang C., Gack MU. ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity. Nature Microbiology, 6(4):467-478. (*Co-first authorship)
[2019. 10] Riedl W., Acharya D., Lee JH., Liu G.,Serman T., Chiang C., Chan YK., Diamond MS., Gack MU. Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity. Cell Host & Microbe, 26(4):493-503. [2017. 05] Lee JH.*, Ostalecki C.*, Wittki S., Dindorf J., Collenburg L., Schierer S., Simon B., Schliep S., Kremmer E., Schuler G., Baur AS. Multi-Epitope Tissue Analysis Reveals SPPL3-mediated ADAM10 Activation as a Key Step in the Transformation of Melanocytes. Science Signaling, 10, 470. (*Co-first authorship)
[2013. 02] Lee JH., Wittki S., Bräu T., Dreyer F.S., Krätzel K., Dindorf J., Johnston I.C., Gross S., Kremmer E., Zeidler R., Schlötzer-Schrehardt U., Lichtenheld M., Saksela K., Harrer T., Schuler G., Federico M., Baur AS. (2013) HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases. Molecular Cell, 49(4):668-79.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2
Xie, Q., Bozzo, C. P., Eiben, L., Noettger, S., Kmiec, D., Nchioua, R., Niemeyer, D., Volcic, M., Lee, J. H., Zech, F., Sparrer, K. M. J., Drosten, C. & Kirchhoff, F., 21 Apr 2023, In: iScience. 26, 4, 106395.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Interferon antagonists encoded by SARS-CoV-2 at a glance
Lee, J. H., Koepke, L., Kirchhoff, F. & Sparrer, K. M. J., Apr 2023, In: Medical Microbiology and Immunology. 212, 2, p. 125-131 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access16 Scopus citations -
The complex role of extracellular vesicles in HIV infection
Lee, J. H., 2023, In: BMB Reports. 56, 6, p. 335-340 6 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus
Lee, J. H., Ostalecki, C., Oberstein, T., Schierer, S., Zinser, E., Eberhardt, M., Blume, K., Plosnita, B., Stich, L., Bruns, H., Coras, R., Vera-Gonzales, J., Maler, M. & Baur, A. S., Mar 2022, In: eBioMedicine. 77, 103903.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141
Naesens, L., Muppala, S., Acharya, D., Nemegeer, J., Bogaert, D., Lee, J. H., Staes, K., Debacker, V., De Bleser, P., De Bruyne, M., De Baere, E., van Gent, M., Liu, G. Q., Lambrecht, B. N., Staal, J., Kerre, T., Beyaert, R., Maelfait, J., Tavernier, S. J. & Gack, M. U. & 1 others, , Nov 2022, In: Science immunology. 7, 77, eabq4531.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations