Personal profile
Education
2001 The Ohio State University, Ph.D. in Biochemistry (Ohio State Biochemistry Program)
1994 Seoul National University, M.S. in Chemistry (Biochemistry Major)
1992 Seoul National University, B.S. in Chemistry
1994 Seoul National University, M.S. in Chemistry (Biochemistry Major)
1992 Seoul National University, B.S. in Chemistry
Professional Experience
2017.09 - current: University of Seoul, Department of Life Science, Proferrsor
2012.09 - 2017.08: University of Seoul, Department of Life Science, Associate Proferrsor
2008.09 – 2012.08: University of Seoul, Department of Life Science, Assistant Proferrsor
2005.10 - 2008.08 Department of Biological Sciences, Stanford University Research Associate
2001.10 - 2005.09 Department of Biological Sciences, Stanford University Post-doctoral Research Fellow
2012.09 - 2017.08: University of Seoul, Department of Life Science, Associate Proferrsor
2008.09 – 2012.08: University of Seoul, Department of Life Science, Assistant Proferrsor
2005.10 - 2008.08 Department of Biological Sciences, Stanford University Research Associate
2001.10 - 2005.09 Department of Biological Sciences, Stanford University Post-doctoral Research Fellow
Research Interests
Lipocalin-2, Astrocyte, Ubiquitin, Protein degradation, Autophagy
Major Research Achievements
[2023.08] B. K. Jung, Y. Park, B. Yoon, J. S. Bae, S. W. Han, J. E. Heo , D. E. Kim*, K. Y. Ryu*, Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage. Autophagy, 19(8), 2296–2317, 2023.
[2022.10] S. W. Han, K. Y. Ryu, Increased clearance of non-biodegradable polystyrene nanoplastics by exocytosis through inhibition of retrograde intracellular transport. Journal of Hazardous Materials, 439, 129576, 2022.
[2021.07] B. Han*, B. K. Jung*, S. H. Park, K. J. Song, M. A. Anwar, K. Y. Ryu#, K. P. Kim#, Polyubiquitin gene Ubb is required for upregulation of Piwi protein level during mouse testis development. Cell Death Discovery, 7, 194, 2021.
[2022.10] S. W. Han, K. Y. Ryu, Increased clearance of non-biodegradable polystyrene nanoplastics by exocytosis through inhibition of retrograde intracellular transport. Journal of Hazardous Materials, 439, 129576, 2022.
[2021.07] B. Han*, B. K. Jung*, S. H. Park, K. J. Song, M. A. Anwar, K. Y. Ryu#, K. P. Kim#, Polyubiquitin gene Ubb is required for upregulation of Piwi protein level during mouse testis development. Cell Death Discovery, 7, 194, 2021.
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Collaborations and top research areas from the last five years
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Improved efficiency of protein aggregate removal using ubiquitin with a signal peptide
Kim, T. Y. & Ryu, K. Y., 2026, In: BMB Reports. 59, 3, p. 187-192 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Signal peptide-directed proteins generated in the endoplasmic reticulum are secreted or degraded via the autophagic pathway
Kim, T. Y., Cho, Y. J. & Ryu, K. Y., Apr 2026, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1873, 4, 120140.Research output: Contribution to journal › Article › peer-review
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Transdermal Drug Delivery System Using Light and Moisture Dual Responsive Hybrid Microneedles
Jeong, H., Kim, H., Bae, J. S., Lee, G., Han, S., Han, Y., Jung, E. E., Ryu, K. Y., Heo, Y. J. & Choi, I., Mar 2025, In: Biochip Journal. 19, 1, p. 62-78 17 p., 112393.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Proteasome inhibition suppresses the induction of lipocalin-2 upon systemic lipopolysaccharide challenge in mice
Bae, J. S., Heo, J. E. & Ryu, K. Y., Dec 2024, In: Molecular Brain. 17, 1, 73.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Recent progress and future directions of the research on nanoplastic-induced neurotoxicity
Han, S. W., Choi, J. & Ryu, K. Y., Feb 2024, In: Neural Regeneration Research. 19, 2, p. 331-335 5 p.Research output: Contribution to journal › Review article › peer-review
Open Access63 Scopus citations