신규접근법을 활용한 화학물질 차세대 위해성평가의 개념과 전망: Accelerating the Pace of Chemical Risk Assessment (APCRA)

Translated title of the contribution: Perspective of Next Generation Risk Assessment (NGRA) using New Approach Methodologies (NAMs): Review on Accelerating the Pace of Chemical Risk Assessment (APCRA) Initiative

Donghyeon Kim, Jinhee Choi

Research output: Contribution to journalArticlepeer-review

Abstract

During the past few decades, toxicity science is shifting from observative to predictive science. New approach methodologies (NAMs), including in chemico, in silico, in vitro approach, gain attention to reduce, refine, replace the whole animal toxicity testing. However, actual acceptances of NAMs in regulatory decision-making have been limited due to low confidence. To address the current constraints, Accelerating the Pace of Chemical Risk Assessment (APCRA) initiative conducted several case studies and presented the perspectives of next generation risk assessment (NGRA). In this review, we suggested a concept and perspectives of NGRA through analysis on APCRA case studies.

Translated title of the contributionPerspective of Next Generation Risk Assessment (NGRA) using New Approach Methodologies (NAMs): Review on Accelerating the Pace of Chemical Risk Assessment (APCRA) Initiative
Original languageKorean
Pages (from-to)19-27
Number of pages9
JournalJournal of the Korean Chemical Society
Volume67
Issue number1
DOIs
StatePublished - 20 Feb 2023

Keywords

  • Accelerate the Pace of Chemical Risk Assessment (APCRA)
  • Chemical management
  • New Approach Methodologies (NAMs)
  • Next Generation Risk Assessment (NGRA)

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