A biomaterial approach to cell reprogramming and differentiation

Joseph Long, Hyejin Kim, Dajeong Kim, Jong Bum Lee, Deok Ho Kim

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The cell reprogramming of somatic cells into pluripotent states and subsequent differentiation into certain phenotypes has helped progress regenerative medicine research and other medical applications. Recent research has used viral vectors to induce this reprogramming; however, limitations include low efficiency and safety concerns. In this review, we discuss how biomaterial methods offer potential avenues for either increasing viability and downstream applicability of viral methods, or providing a safer alternative. The use of non-viral delivery systems, such as electroporation, micro/nanoparticles, nucleic acids and the modulation of culture substrate topography and stiffness, has generated valuable insights regarding cell reprogramming.

Original languageEnglish
Pages (from-to)2375-2389
Number of pages15
JournalJournal of Materials Chemistry B
Issue number13
StatePublished - 2017


Dive into the research topics of 'A biomaterial approach to cell reprogramming and differentiation'. Together they form a unique fingerprint.

Cite this