A biomimetic ocular prosthesis system: emulating autonomic pupil and corneal reflections

Seongchan Kim; Yoon Young Choi; Taewan Kim; Yong Min Kim; Dong Hae Ho; Young Jin Choi; Dong Gue Roe; Ju Hee Lee; Joongpill Park; Ji Woong Choi; Jeong Won Kim; Jin Hong Park; Sae Byeok Jo; Hong Chul Moon; Sohee Jeong; Jeong Ho Cho

doi:10.1038/s41467-022-34448-6

A biomimetic ocular prosthesis system: emulating autonomic pupil and corneal reflections

Seongchan Kim, Yoon Young Choi, Taewan Kim, Yong Min Kim, Dong Hae Ho, Young Jin Choi, Dong Gue Roe, Ju Hee Lee, Joongpill Park, Ji Woong Choi, Jeong Won Kim, Jin Hong Park, Sae Byeok Jo, Hong Chul Moon, Sohee Jeong, Jeong Ho Cho

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The human light modulation response allows humans to perceive objects clearly by receiving the appropriate amount of light from the environment. This paper proposes a biomimetic ocular prosthesis system that mimics the human light modulation response capable of pupil and corneal reflections. First, photoinduced synaptic properties of the quantum dot embedded photonic synapse and its biosimilar signal transmission is confirmed. Subsequently, the pupillary light reflex is emulated by incorporating the quantum dot embedded photonic synapse, electrochromic device, and CMOS components. Moreover, a solenoid-based eyelid is connected to the pupillary light reflex system to emulate the corneal reflex. The proposed ocular prosthesis system represents a platform for biomimetic prosthesis that can accommodate an appropriate amount of stimulus by self-regulating the intensity of external stimuli.

Original language	English
Article number	6760
Journal	Nature Communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-34448-6
State	Published - Dec 2022

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Kim, S., Choi, Y. Y., Kim, T., Kim, Y. M., Ho, D. H., Choi, Y. J., Roe, D. G., Lee, J. H., Park, J., Choi, J. W., Kim, J. W., Park, J. H., Jo, S. B., Moon, H. C., Jeong, S., & Cho, J. H. (2022). A biomimetic ocular prosthesis system: emulating autonomic pupil and corneal reflections. Nature Communications, 13(1), Article 6760. https://doi.org/10.1038/s41467-022-34448-6

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abstract = "The human light modulation response allows humans to perceive objects clearly by receiving the appropriate amount of light from the environment. This paper proposes a biomimetic ocular prosthesis system that mimics the human light modulation response capable of pupil and corneal reflections. First, photoinduced synaptic properties of the quantum dot embedded photonic synapse and its biosimilar signal transmission is confirmed. Subsequently, the pupillary light reflex is emulated by incorporating the quantum dot embedded photonic synapse, electrochromic device, and CMOS components. Moreover, a solenoid-based eyelid is connected to the pupillary light reflex system to emulate the corneal reflex. The proposed ocular prosthesis system represents a platform for biomimetic prosthesis that can accommodate an appropriate amount of stimulus by self-regulating the intensity of external stimuli.",

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AU - Ho, Dong Hae

AU - Choi, Young Jin

AU - Roe, Dong Gue

AU - Lee, Ju Hee

AU - Park, Joongpill

AU - Choi, Ji Woong

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AB - The human light modulation response allows humans to perceive objects clearly by receiving the appropriate amount of light from the environment. This paper proposes a biomimetic ocular prosthesis system that mimics the human light modulation response capable of pupil and corneal reflections. First, photoinduced synaptic properties of the quantum dot embedded photonic synapse and its biosimilar signal transmission is confirmed. Subsequently, the pupillary light reflex is emulated by incorporating the quantum dot embedded photonic synapse, electrochromic device, and CMOS components. Moreover, a solenoid-based eyelid is connected to the pupillary light reflex system to emulate the corneal reflex. The proposed ocular prosthesis system represents a platform for biomimetic prosthesis that can accommodate an appropriate amount of stimulus by self-regulating the intensity of external stimuli.

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A biomimetic ocular prosthesis system: emulating autonomic pupil and corneal reflections

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