A fluorescent and colorimetric Schiff base chemosensor for the detection of Zn2+ and Cu2+: Application in live cell imaging and colorimetric test kit

Min Seon Kim; Tae Geun Jo; Minuk Yang; Jiyeon Han; Mi Hee Lim; Cheal Kim

doi:10.1016/j.saa.2018.11.058

A fluorescent and colorimetric Schiff base chemosensor for the detection of Zn²⁺ and Cu²⁺: Application in live cell imaging and colorimetric test kit

Min Seon Kim, Tae Geun Jo, Minuk Yang, Jiyeon Han, Mi Hee Lim, Cheal Kim

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A novel Schiff base chemosensor HMID, ((E)‑1‑((2‑hydroxy‑3‑methoxybenzylidene)amino)imidazolidine‑2,4‑dione), have been designed and synthesized. Sensor HMID showed a selectivity to Zn²⁺ through fluorescence enhancement in aqueous solution. Its detection limit was analyzed as 11.9 μM. Importantly, compound HMID could be applied to image Zn²⁺ in live cells. Detection mechanism of Zn²⁺ by HMID was suggested to be an effect of chelation-enhanced fluorescence (CHEF) by DFT calculations. Moreover, HMID could detect Cu²⁺ with a change of color from colorless to pink. The selective detection mechanism of Cu²⁺ by HMID was demonstrated to be the promotion of intramolecular charge transfer band by DFT calculations. Additionally, HMID could be employed as a naked-eye colorimetric kit for Cu²⁺. Therefore, HMID has the ability as a ‘single sensor for dual targets’.

Original language	English
Pages (from-to)	34-43
Number of pages	10
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	211
DOIs	https://doi.org/10.1016/j.saa.2018.11.058
State	Published - 15 Mar 2019

Keywords

Cell imaging
Chemosensor
Colorimetric
Copper ion
Fluorescent
Zinc ion

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10.1016/j.saa.2018.11.058

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@article{2a1921843dc6407683b7b7590f89aa36,

title = "A fluorescent and colorimetric Schiff base chemosensor for the detection of Zn2+ and Cu2+: Application in live cell imaging and colorimetric test kit",

abstract = "A novel Schiff base chemosensor HMID, ((E)‑1‑((2‑hydroxy‑3‑methoxybenzylidene)amino)imidazolidine‑2,4‑dione), have been designed and synthesized. Sensor HMID showed a selectivity to Zn2+ through fluorescence enhancement in aqueous solution. Its detection limit was analyzed as 11.9 μM. Importantly, compound HMID could be applied to image Zn2+ in live cells. Detection mechanism of Zn2+ by HMID was suggested to be an effect of chelation-enhanced fluorescence (CHEF) by DFT calculations. Moreover, HMID could detect Cu2+ with a change of color from colorless to pink. The selective detection mechanism of Cu2+ by HMID was demonstrated to be the promotion of intramolecular charge transfer band by DFT calculations. Additionally, HMID could be employed as a naked-eye colorimetric kit for Cu2+. Therefore, HMID has the ability as a {\textquoteleft}single sensor for dual targets{\textquoteright}.",

keywords = "Cell imaging, Chemosensor, Colorimetric, Copper ion, Fluorescent, Zinc ion",

author = "Kim, {Min Seon} and Jo, {Tae Geun} and Minuk Yang and Jiyeon Han and Lim, {Mi Hee} and Cheal Kim",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2019",

month = mar,

day = "15",

doi = "10.1016/j.saa.2018.11.058",

language = "English",

volume = "211",

pages = "34--43",

journal = "Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy",

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}

A fluorescent and colorimetric Schiff base chemosensor for the detection of Zn²⁺ and Cu²⁺: Application in live cell imaging and colorimetric test kit. / Kim, Min Seon; Jo, Tae Geun; Yang, Minuk et al.
In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Vol. 211, 15.03.2019, p. 34-43.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A fluorescent and colorimetric Schiff base chemosensor for the detection of Zn2+ and Cu2+

T2 - Application in live cell imaging and colorimetric test kit

AU - Kim, Min Seon

AU - Jo, Tae Geun

AU - Yang, Minuk

AU - Han, Jiyeon

AU - Lim, Mi Hee

AU - Kim, Cheal

PY - 2019/3/15

Y1 - 2019/3/15

N2 - A novel Schiff base chemosensor HMID, ((E)‑1‑((2‑hydroxy‑3‑methoxybenzylidene)amino)imidazolidine‑2,4‑dione), have been designed and synthesized. Sensor HMID showed a selectivity to Zn2+ through fluorescence enhancement in aqueous solution. Its detection limit was analyzed as 11.9 μM. Importantly, compound HMID could be applied to image Zn2+ in live cells. Detection mechanism of Zn2+ by HMID was suggested to be an effect of chelation-enhanced fluorescence (CHEF) by DFT calculations. Moreover, HMID could detect Cu2+ with a change of color from colorless to pink. The selective detection mechanism of Cu2+ by HMID was demonstrated to be the promotion of intramolecular charge transfer band by DFT calculations. Additionally, HMID could be employed as a naked-eye colorimetric kit for Cu2+. Therefore, HMID has the ability as a ‘single sensor for dual targets’.

AB - A novel Schiff base chemosensor HMID, ((E)‑1‑((2‑hydroxy‑3‑methoxybenzylidene)amino)imidazolidine‑2,4‑dione), have been designed and synthesized. Sensor HMID showed a selectivity to Zn2+ through fluorescence enhancement in aqueous solution. Its detection limit was analyzed as 11.9 μM. Importantly, compound HMID could be applied to image Zn2+ in live cells. Detection mechanism of Zn2+ by HMID was suggested to be an effect of chelation-enhanced fluorescence (CHEF) by DFT calculations. Moreover, HMID could detect Cu2+ with a change of color from colorless to pink. The selective detection mechanism of Cu2+ by HMID was demonstrated to be the promotion of intramolecular charge transfer band by DFT calculations. Additionally, HMID could be employed as a naked-eye colorimetric kit for Cu2+. Therefore, HMID has the ability as a ‘single sensor for dual targets’.

KW - Cell imaging

KW - Chemosensor

KW - Colorimetric

KW - Copper ion

KW - Fluorescent

KW - Zinc ion

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A fluorescent and colorimetric Schiff base chemosensor for the detection of Zn²⁺ and Cu²⁺: Application in live cell imaging and colorimetric test kit

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