A highly sensitive and selective fluorescent chemosensor for the sequential recognition of Zn2+ and S2− in living cells and aqueous media

Jin Yeong Yun; Tae Geun Jo; Jiyeon Han; Hyo Jung Jang; Mi Hee Lim; Cheal Kim

doi:10.1016/j.snb.2017.09.136

A highly sensitive and selective fluorescent chemosensor for the sequential recognition of Zn²⁺ and S²⁻ in living cells and aqueous media

Jin Yeong Yun, Tae Geun Jo, Jiyeon Han, Hyo Jung Jang, Mi Hee Lim, Cheal Kim

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

A new highly selective chemosensor 1 (E)-5-((2-hydroxybenzylidene)amino)-1H-imidazole-4-carboxamide was designed and synthesized for the sequential recognition of Zn²⁺ and S²⁻ in a near-perfect aqueous media. The sensor 1 exhibited a green color fluorescence in the presence of Zn²⁺. The detection limit (1.18 μM) of 1 for Zn²⁺ is much lower than World Health Organization guideline (76 μM) in drinking water. 1 can detect and quantify Zn²⁺ in real water samples and the sensing mechanism of Zn²⁺ by 1 was explained by DFT calculations. Moreover, resulting 1-Zn²⁺ complex can detect hydrogen sulfide through turn-off fluorescent change, without any anion interference. The detection limit (2.60 μM) of 1-Zn²⁺ complex for S²⁻ was much lower than EPA guideline (7.8 mM) by odor in drinking water. Furthermore, sensor 1 could detect sequentially Zn²⁺ and S²⁻ in living cells.

Original language	English
Pages (from-to)	3108-3116
Number of pages	9
Journal	Sensors and Actuators, B: Chemical
Volume	255
DOIs	https://doi.org/10.1016/j.snb.2017.09.136
State	Published - Feb 2018

Keywords

Cell imaging
Fluorescence
Sequential detection
Sulfide
Theoretical calculations
Zinc

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title = "A highly sensitive and selective fluorescent chemosensor for the sequential recognition of Zn2+ and S2− in living cells and aqueous media",

abstract = "A new highly selective chemosensor 1 (E)-5-((2-hydroxybenzylidene)amino)-1H-imidazole-4-carboxamide was designed and synthesized for the sequential recognition of Zn2+ and S2− in a near-perfect aqueous media. The sensor 1 exhibited a green color fluorescence in the presence of Zn2+. The detection limit (1.18 μM) of 1 for Zn2+ is much lower than World Health Organization guideline (76 μM) in drinking water. 1 can detect and quantify Zn2+ in real water samples and the sensing mechanism of Zn2+ by 1 was explained by DFT calculations. Moreover, resulting 1-Zn2+ complex can detect hydrogen sulfide through turn-off fluorescent change, without any anion interference. The detection limit (2.60 μM) of 1-Zn2+ complex for S2− was much lower than EPA guideline (7.8 mM) by odor in drinking water. Furthermore, sensor 1 could detect sequentially Zn2+ and S2− in living cells.",

keywords = "Cell imaging, Fluorescence, Sequential detection, Sulfide, Theoretical calculations, Zinc",

author = "Yun, {Jin Yeong} and Jo, {Tae Geun} and Jiyeon Han and Jang, {Hyo Jung} and Lim, {Mi Hee} and Cheal Kim",

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AU - Yun, Jin Yeong

AU - Jo, Tae Geun

AU - Han, Jiyeon

AU - Jang, Hyo Jung

AU - Lim, Mi Hee

AU - Kim, Cheal

PY - 2018/2

Y1 - 2018/2

N2 - A new highly selective chemosensor 1 (E)-5-((2-hydroxybenzylidene)amino)-1H-imidazole-4-carboxamide was designed and synthesized for the sequential recognition of Zn2+ and S2− in a near-perfect aqueous media. The sensor 1 exhibited a green color fluorescence in the presence of Zn2+. The detection limit (1.18 μM) of 1 for Zn2+ is much lower than World Health Organization guideline (76 μM) in drinking water. 1 can detect and quantify Zn2+ in real water samples and the sensing mechanism of Zn2+ by 1 was explained by DFT calculations. Moreover, resulting 1-Zn2+ complex can detect hydrogen sulfide through turn-off fluorescent change, without any anion interference. The detection limit (2.60 μM) of 1-Zn2+ complex for S2− was much lower than EPA guideline (7.8 mM) by odor in drinking water. Furthermore, sensor 1 could detect sequentially Zn2+ and S2− in living cells.

AB - A new highly selective chemosensor 1 (E)-5-((2-hydroxybenzylidene)amino)-1H-imidazole-4-carboxamide was designed and synthesized for the sequential recognition of Zn2+ and S2− in a near-perfect aqueous media. The sensor 1 exhibited a green color fluorescence in the presence of Zn2+. The detection limit (1.18 μM) of 1 for Zn2+ is much lower than World Health Organization guideline (76 μM) in drinking water. 1 can detect and quantify Zn2+ in real water samples and the sensing mechanism of Zn2+ by 1 was explained by DFT calculations. Moreover, resulting 1-Zn2+ complex can detect hydrogen sulfide through turn-off fluorescent change, without any anion interference. The detection limit (2.60 μM) of 1-Zn2+ complex for S2− was much lower than EPA guideline (7.8 mM) by odor in drinking water. Furthermore, sensor 1 could detect sequentially Zn2+ and S2− in living cells.

KW - Cell imaging

KW - Fluorescence

KW - Sequential detection

KW - Sulfide

KW - Theoretical calculations

KW - Zinc

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ER -

A highly sensitive and selective fluorescent chemosensor for the sequential recognition of Zn²⁺ and S²⁻ in living cells and aqueous media

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Keywords

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