A novel “off-on” type fluorescent chemosensor for detection of Zn2+ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo

Jae Min Jung, Ji Hye Kang, Jiyeon Han, Hyojin Lee, Mi Hee Lim, Ki Tae Kim, Cheal Kim

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

We reported a new quinoline-based fluorescent probe 1 for Zn2+ and S2−. 1 showed a highly selective fluorescence enhancement toward Zn2+ over other metal ions including Cd2+, and the resulting 1-Zn2+ complex could detect only S2− among the various anions. The detection limits (0.09 μM and 0.88 μM) for Zn2+ and S2− were much lower than recommended values (76 μM for Zn2+ and 14.8 μM for S2−) by WHO. Their recognition mechanisms were explained by Job plots, UV–vis titrations, 1H NMR titrations, ESI-mass, and theoretical calculations. Moreover, compound 1 with the great photostability and low biotoxicity showed sequentially off-on-off fluorescent bio-imaging of Zn2+ and S2− in both HeLa cells and live zebrafish larvae.

Original languageEnglish
Pages (from-to)58-69
Number of pages12
JournalSensors and Actuators, B: Chemical
Volume267
DOIs
StatePublished - 15 Aug 2018

Keywords

  • Cell and zebrafish imaging
  • Fluorescent chemosensor
  • Sulfide
  • Theoretical calculations
  • Zinc ion

Fingerprint

Dive into the research topics of 'A novel “off-on” type fluorescent chemosensor for detection of Zn2+ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo'. Together they form a unique fingerprint.

Cite this