A novel “off-on” type fluorescent chemosensor for detection of Zn2+ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo

Jae Min Jung; Ji Hye Kang; Jiyeon Han; Hyojin Lee; Mi Hee Lim; Ki Tae Kim; Cheal Kim

doi:10.1016/j.snb.2018.03.063

A novel “off-on” type fluorescent chemosensor for detection of Zn²⁺ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo

Jae Min Jung, Ji Hye Kang, Jiyeon Han, Hyojin Lee, Mi Hee Lim, Ki Tae Kim, Cheal Kim

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

We reported a new quinoline-based fluorescent probe 1 for Zn²⁺ and S²⁻. 1 showed a highly selective fluorescence enhancement toward Zn²⁺ over other metal ions including Cd²⁺, and the resulting 1-Zn²⁺ complex could detect only S²⁻ among the various anions. The detection limits (0.09 μM and 0.88 μM) for Zn²⁺ and S²⁻ were much lower than recommended values (76 μM for Zn²⁺ and 14.8 μM for S²⁻) by WHO. Their recognition mechanisms were explained by Job plots, UV–vis titrations, ¹H NMR titrations, ESI-mass, and theoretical calculations. Moreover, compound 1 with the great photostability and low biotoxicity showed sequentially off-on-off fluorescent bio-imaging of Zn²⁺ and S²⁻ in both HeLa cells and live zebrafish larvae.

Original language	English
Pages (from-to)	58-69
Number of pages	12
Journal	Sensors and Actuators, B: Chemical
Volume	267
DOIs	https://doi.org/10.1016/j.snb.2018.03.063
State	Published - 15 Aug 2018

Keywords

Cell and zebrafish imaging
Fluorescent chemosensor
Sulfide
Theoretical calculations
Zinc ion

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10.1016/j.snb.2018.03.063

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title = "A novel “off-on” type fluorescent chemosensor for detection of Zn2+ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo",

abstract = "We reported a new quinoline-based fluorescent probe 1 for Zn2+ and S2−. 1 showed a highly selective fluorescence enhancement toward Zn2+ over other metal ions including Cd2+, and the resulting 1-Zn2+ complex could detect only S2− among the various anions. The detection limits (0.09 μM and 0.88 μM) for Zn2+ and S2− were much lower than recommended values (76 μM for Zn2+ and 14.8 μM for S2−) by WHO. Their recognition mechanisms were explained by Job plots, UV–vis titrations, 1H NMR titrations, ESI-mass, and theoretical calculations. Moreover, compound 1 with the great photostability and low biotoxicity showed sequentially off-on-off fluorescent bio-imaging of Zn2+ and S2− in both HeLa cells and live zebrafish larvae.",

keywords = "Cell and zebrafish imaging, Fluorescent chemosensor, Sulfide, Theoretical calculations, Zinc ion",

author = "Jung, {Jae Min} and Kang, {Ji Hye} and Jiyeon Han and Hyojin Lee and Lim, {Mi Hee} and Kim, {Ki Tae} and Cheal Kim",

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year = "2018",

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day = "15",

doi = "10.1016/j.snb.2018.03.063",

language = "English",

volume = "267",

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journal = "Sensors and Actuators, B: Chemical",

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A novel “off-on” type fluorescent chemosensor for detection of Zn²⁺ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo. / Jung, Jae Min; Kang, Ji Hye; Han, Jiyeon et al.
In: Sensors and Actuators, B: Chemical, Vol. 267, 15.08.2018, p. 58-69.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A novel “off-on” type fluorescent chemosensor for detection of Zn2+ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo

AU - Jung, Jae Min

AU - Kang, Ji Hye

AU - Han, Jiyeon

AU - Lee, Hyojin

AU - Lim, Mi Hee

AU - Kim, Ki Tae

AU - Kim, Cheal

PY - 2018/8/15

Y1 - 2018/8/15

N2 - We reported a new quinoline-based fluorescent probe 1 for Zn2+ and S2−. 1 showed a highly selective fluorescence enhancement toward Zn2+ over other metal ions including Cd2+, and the resulting 1-Zn2+ complex could detect only S2− among the various anions. The detection limits (0.09 μM and 0.88 μM) for Zn2+ and S2− were much lower than recommended values (76 μM for Zn2+ and 14.8 μM for S2−) by WHO. Their recognition mechanisms were explained by Job plots, UV–vis titrations, 1H NMR titrations, ESI-mass, and theoretical calculations. Moreover, compound 1 with the great photostability and low biotoxicity showed sequentially off-on-off fluorescent bio-imaging of Zn2+ and S2− in both HeLa cells and live zebrafish larvae.

AB - We reported a new quinoline-based fluorescent probe 1 for Zn2+ and S2−. 1 showed a highly selective fluorescence enhancement toward Zn2+ over other metal ions including Cd2+, and the resulting 1-Zn2+ complex could detect only S2− among the various anions. The detection limits (0.09 μM and 0.88 μM) for Zn2+ and S2− were much lower than recommended values (76 μM for Zn2+ and 14.8 μM for S2−) by WHO. Their recognition mechanisms were explained by Job plots, UV–vis titrations, 1H NMR titrations, ESI-mass, and theoretical calculations. Moreover, compound 1 with the great photostability and low biotoxicity showed sequentially off-on-off fluorescent bio-imaging of Zn2+ and S2− in both HeLa cells and live zebrafish larvae.

KW - Cell and zebrafish imaging

KW - Fluorescent chemosensor

KW - Sulfide

KW - Theoretical calculations

KW - Zinc ion

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JO - Sensors and Actuators, B: Chemical

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A novel “off-on” type fluorescent chemosensor for detection of Zn²⁺ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo

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