A review of the influence of treatment strategies on antibiotic resistant bacteria and antibiotic resistance genes

Virender K. Sharma, Natalie Johnson, Leslie Cizmas, Thomas J. McDonald, Hyunook Kim

Research output: Contribution to journalArticlepeer-review

571 Scopus citations

Abstract

Antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) in the aquatic environment have become an emerging contaminant issue, which has implications for human and ecological health. This review begins with an introduction to the occurrence of ARB and ARG in different environmental systems such as natural environments and drinking water resources. For example, ARG or ARB with resistance to ciprofloxacin, sulfamethoxazole, trimethoprim, quinolone, vancomycin, or tetracycline (e.g., tet(A), tet(B), tet(C), tet(G), tet(O), tet(M), tet(W), sul I, and sul II) have been detected in the environment. The development of resistance may be intrinsic, may be acquired through spontaneous mutations (de novo), or may occur due to horizontal gene transfer from donor bacteria, phages, or free DNA to recipient bacteria. An overview is also provided of the current knowledge regarding inactivation of ARB and ARG, and the mechanism of the effects of different disinfection processes in water and wastewater (chlorination, UV irradiation, Fenton reaction, ozonation, and photocatalytic oxidation). The effects of constructed wetlands and nanotechnology on ARB and ARG are also summarized.

Original languageEnglish
Pages (from-to)702-714
Number of pages13
JournalChemosphere
Volume150
DOIs
StatePublished - 1 May 2016

Keywords

  • Antibiotic resistance genes
  • Antibiotic resistant bacteria
  • Disinfection
  • Mechanism
  • Nanoparticles
  • Wetlands

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