A water-soluble fluorescence chemosensor for the sequential detection of Zn2+ and pyrophosphate in living cells and zebrafish

Ji Hye Kang; Jiyeon Han; Hyojin Lee; Mi Hee Lim; Ki Tae Kim; Cheal Kim

doi:10.1016/j.dyepig.2018.01.039

A water-soluble fluorescence chemosensor for the sequential detection of Zn²⁺ and pyrophosphate in living cells and zebrafish

Ji Hye Kang, Jiyeon Han, Hyojin Lee, Mi Hee Lim, Ki Tae Kim, Cheal Kim

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

A new simple aminohydantoin-based fluorescent chemosensor 1 was designed for sequential detection of Zn²⁺ and pyrophosphate in a near-perfect aqueous solution. 1 exhibited significant fluorescence intensity in the presence of Zn²⁺, and the resulting 1-Zn²⁺ complex showed subsequently the fluorescent quenching with pyrophosphate. The detection limit (0.32 μM) of 1 for Zn²⁺ was far lower than the guideline of World Health Organization in drinking water. 1 was used to determine Zn²⁺ concentration in various water samples. In addition, chemosensor 1 could be applied to sequentially detect Zn²⁺ and pyrophosphate in living cells and zebrafish. The sensing mechanism of Zn²⁺ by 1 was proposed to be an intramolecular charge transfer with theoretical calculations.

Original language	English
Pages (from-to)	131-138
Number of pages	8
Journal	Dyes and Pigments
Volume	152
DOIs	https://doi.org/10.1016/j.dyepig.2018.01.039
State	Published - May 2018

Keywords

Cell imaging
Fluorescent chemosensor
Pyrophosphate
Theoretical calculations
Zebrafish
Zinc ion

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10.1016/j.dyepig.2018.01.039

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title = "A water-soluble fluorescence chemosensor for the sequential detection of Zn2+ and pyrophosphate in living cells and zebrafish",

abstract = "A new simple aminohydantoin-based fluorescent chemosensor 1 was designed for sequential detection of Zn2+ and pyrophosphate in a near-perfect aqueous solution. 1 exhibited significant fluorescence intensity in the presence of Zn2+, and the resulting 1-Zn2+ complex showed subsequently the fluorescent quenching with pyrophosphate. The detection limit (0.32 μM) of 1 for Zn2+ was far lower than the guideline of World Health Organization in drinking water. 1 was used to determine Zn2+ concentration in various water samples. In addition, chemosensor 1 could be applied to sequentially detect Zn2+ and pyrophosphate in living cells and zebrafish. The sensing mechanism of Zn2+ by 1 was proposed to be an intramolecular charge transfer with theoretical calculations.",

keywords = "Cell imaging, Fluorescent chemosensor, Pyrophosphate, Theoretical calculations, Zebrafish, Zinc ion",

author = "Kang, {Ji Hye} and Jiyeon Han and Hyojin Lee and Lim, {Mi Hee} and Kim, {Ki Tae} and Cheal Kim",

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AU - Kang, Ji Hye

AU - Han, Jiyeon

AU - Lee, Hyojin

AU - Lim, Mi Hee

AU - Kim, Ki Tae

AU - Kim, Cheal

PY - 2018/5

Y1 - 2018/5

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AB - A new simple aminohydantoin-based fluorescent chemosensor 1 was designed for sequential detection of Zn2+ and pyrophosphate in a near-perfect aqueous solution. 1 exhibited significant fluorescence intensity in the presence of Zn2+, and the resulting 1-Zn2+ complex showed subsequently the fluorescent quenching with pyrophosphate. The detection limit (0.32 μM) of 1 for Zn2+ was far lower than the guideline of World Health Organization in drinking water. 1 was used to determine Zn2+ concentration in various water samples. In addition, chemosensor 1 could be applied to sequentially detect Zn2+ and pyrophosphate in living cells and zebrafish. The sensing mechanism of Zn2+ by 1 was proposed to be an intramolecular charge transfer with theoretical calculations.

KW - Cell imaging

KW - Fluorescent chemosensor

KW - Pyrophosphate

KW - Theoretical calculations

KW - Zebrafish

KW - Zinc ion

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A water-soluble fluorescence chemosensor for the sequential detection of Zn²⁺ and pyrophosphate in living cells and zebrafish

Abstract

Keywords

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