A water-soluble fluorescence chemosensor for the sequential detection of Zn2+ and pyrophosphate in living cells and zebrafish

Ji Hye Kang, Jiyeon Han, Hyojin Lee, Mi Hee Lim, Ki Tae Kim, Cheal Kim

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

A new simple aminohydantoin-based fluorescent chemosensor 1 was designed for sequential detection of Zn2+ and pyrophosphate in a near-perfect aqueous solution. 1 exhibited significant fluorescence intensity in the presence of Zn2+, and the resulting 1-Zn2+ complex showed subsequently the fluorescent quenching with pyrophosphate. The detection limit (0.32 μM) of 1 for Zn2+ was far lower than the guideline of World Health Organization in drinking water. 1 was used to determine Zn2+ concentration in various water samples. In addition, chemosensor 1 could be applied to sequentially detect Zn2+ and pyrophosphate in living cells and zebrafish. The sensing mechanism of Zn2+ by 1 was proposed to be an intramolecular charge transfer with theoretical calculations.

Original languageEnglish
Pages (from-to)131-138
Number of pages8
JournalDyes and Pigments
Volume152
DOIs
StatePublished - May 2018

Keywords

  • Cell imaging
  • Fluorescent chemosensor
  • Pyrophosphate
  • Theoretical calculations
  • Zebrafish
  • Zinc ion

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