An advanced centrifugal microsystem toward high-throughput multiplex colloidal nanocrystal synthesis

Byung Hyun Park, Dahin Kim, Jae Hwan Jung, Seung Jun Oh, Goro Choi, Doh C. Lee, Tae Seok Seo

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


An advanced centrifugal microsystem is developed which has capability of automatic and programmed chemical reagent loading and reactions to screen the colloidal nanocrystal synthesis in a high-throughput manner. As a proof of concept, triplicate synthetic reactions for water-soluble multi-color CdS nanocrystals are executed under ten different conditions on a chip. The proposed disk-shaped microdevice contains a top layer for distributing the reagents through zig-zag continuous channels and a bottom layer for 30 functional units, each of which is composed of a reaction chamber and three reservoirs connected with a control, a precursor, and a basic solution, respectively. All the reservoirs are linked to the main channel via different microfluidic channel dimension, and the main channel is directed to the reaction chamber. Through rotational speed control, the three solutions are sequentially loaded to the reaction chamber with precise volume, and the multiplex CdS nanocrystals synthesis is processed. By tuning the concentration of sulfur in a control solution, multi-color CdS nanocrystals are produced from green to red depending on the molar ratios of Cd2+ to S2-.

Original languageEnglish
Pages (from-to)927-933
Number of pages7
JournalSensors and Actuators, B: Chemical
StatePublished - 31 Mar 2015


  • Centrifugal microfluidics
  • Colloidal nanocrystals
  • High-throughput screening
  • Microreactors


Dive into the research topics of 'An advanced centrifugal microsystem toward high-throughput multiplex colloidal nanocrystal synthesis'. Together they form a unique fingerprint.

Cite this