An enzymatically self-assembled DNA patch for enhanced blood coagulation

Dajeong Kim; Jieun Kim; Jong Bum Lee

doi:10.1039/d0cc00974a

An enzymatically self-assembled DNA patch for enhanced blood coagulation

Dajeong Kim, Jieun Kim, Jong Bum Lee

Department of Chemical Engineering

University of Seoul

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

DNA has been widely investigated as a carrier for drug delivery. Here, we describe a macroscopic DNA film that has been generated enzymatically. This DNA film was subsequently coated with thrombin (TB) using an aptamer-protein interaction, to expedite hemostasis over a large area. The DNA film coated with TB (DNA patch) significantly improved plasma hemostasis by acting as a coagulative scaffold for TB, as well as carrying localized TB. This study elucidates the benefits of using enzymatic amplification-based DNA structures in the context of topical drug treatment.

Original language	English
Pages (from-to)	5917-5920
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	44
DOIs	https://doi.org/10.1039/d0cc00974a
State	Published - 4 Jun 2020

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10.1039/d0cc00974a

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abstract = "DNA has been widely investigated as a carrier for drug delivery. Here, we describe a macroscopic DNA film that has been generated enzymatically. This DNA film was subsequently coated with thrombin (TB) using an aptamer-protein interaction, to expedite hemostasis over a large area. The DNA film coated with TB (DNA patch) significantly improved plasma hemostasis by acting as a coagulative scaffold for TB, as well as carrying localized TB. This study elucidates the benefits of using enzymatic amplification-based DNA structures in the context of topical drug treatment.",

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N2 - DNA has been widely investigated as a carrier for drug delivery. Here, we describe a macroscopic DNA film that has been generated enzymatically. This DNA film was subsequently coated with thrombin (TB) using an aptamer-protein interaction, to expedite hemostasis over a large area. The DNA film coated with TB (DNA patch) significantly improved plasma hemostasis by acting as a coagulative scaffold for TB, as well as carrying localized TB. This study elucidates the benefits of using enzymatic amplification-based DNA structures in the context of topical drug treatment.

AB - DNA has been widely investigated as a carrier for drug delivery. Here, we describe a macroscopic DNA film that has been generated enzymatically. This DNA film was subsequently coated with thrombin (TB) using an aptamer-protein interaction, to expedite hemostasis over a large area. The DNA film coated with TB (DNA patch) significantly improved plasma hemostasis by acting as a coagulative scaffold for TB, as well as carrying localized TB. This study elucidates the benefits of using enzymatic amplification-based DNA structures in the context of topical drug treatment.

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An enzymatically self-assembled DNA patch for enhanced blood coagulation

Abstract

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