Association between HOMA-IR, fasting insulin and fasting glucose with coronary heart disease mortality in nondiabetic men: a 20-year observational study

Sudhir Kurl, Francesco Zaccardi, Vivian N. Onaemo, Sae Young Jae, Jussi Kauhanen, Kimmo Ronkainen, Jari A. Laukkanen

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Whether glucose and insulin are differently associated with the risk of coronary heart disease (CHD) mortality is unclear. We aimed to estimate the association between insulin resistance (estimated by the homeostasis model assessment for insulin resistance, HOMA-IR), fasting serum insulin (FI) and fasting plasma glucose (FPG) with incident CHD mortality in a prospective study including middle-aged nondiabetic Finnish men. During an average follow-up of 20 years, 273 (11 %) CHD deaths occurred. In a multivariable Cox regression analysis adjusted for age, body mass index, systolic blood pressure, serum LDL-cholesterol, cigarette smoking, history of CHD, alcohol consumption, blood leukocytes and plasma fibrinogen, the hazard ratios (HRs) for CHD mortality comparing top versus bottom quartiles were as follows: 1.69 (95 % CI: 1.15–2.48; p = 0.008) for HOMA-IR; 1.59 (1.09–2.32; p = 0.016) for FI; and 1.26 (0.90–1.76; p = 0.173) for FPG. These findings suggest that IR and FI, but not FPG, are independent risk factors for CHD mortality. Further studies could help clarify these results in terms of screening and risk stratification, causality of the associations, and therapeutical implications.

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalActa Diabetologica
Volume52
Issue number1
DOIs
StatePublished - Feb 2015

Keywords

  • Coronary heart disease
  • Insulin resistance
  • Men
  • Mortality
  • Risk factors

Fingerprint

Dive into the research topics of 'Association between HOMA-IR, fasting insulin and fasting glucose with coronary heart disease mortality in nondiabetic men: a 20-year observational study'. Together they form a unique fingerprint.

Cite this