Biomimetic sensors for the heavy metal detection

Suseung Lee, Inhee Choi, Surin Hong, Young In Yang, Jeongjin Lee, Hyeon Don Song, Jongheop Yi, Taewook Kang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations


Specific interactions between heavy metal ions and biomaterials have advantages in the sensitive and selective detection of the metal ions. In this study, Cu-demetallated form of Cu/Zn-superoxide dismutase (SODl) protein was applied as a sensing probe in order to detect Cu(II) ions selectively via surface plasmon resonance (SPR) analysis. Because demetallated metalloproteins have vacant specific metal-binding sites in their own structures, Cu-demetallated SODl protein can successfully form stable complex with Cu(II) ion. By applying the properties as a sensing principle, we designed the Cu(lI)-selective sensor chip with Cu-demetallated SODl protein. When Cu(II) ions were exposed to the fabricated sensor chips, their interaction was quantitatively measured via SPR analysis, and it was proportional to the concentrations of Cu(lI) ions.This result reveals successful development of biosensor for the label-free selective detection of Cu(II) ions.

Original languageEnglish
Title of host publicationIEEE Sensors 2009 Conference - SENSORS 2009
Number of pages3
StatePublished - 2009
EventIEEE Sensors 2009 Conference - SENSORS 2009 - Christchurch, New Zealand
Duration: 25 Oct 200928 Oct 2009

Publication series

NameProceedings of IEEE Sensors


ConferenceIEEE Sensors 2009 Conference - SENSORS 2009
Country/TerritoryNew Zealand


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