Construction of a two-dimensional DNA-RNA hybridized membrane for collecting tumor-derived exosomes

Yoonbin Ji; Dajeong Kim; Hyejin Kim; Sangwoo Han; Jong Bum Lee

doi:10.1039/d1cc05924f

Construction of a two-dimensional DNA-RNA hybridized membrane for collecting tumor-derived exosomes

Yoonbin Ji, Dajeong Kim, Hyejin Kim, Sangwoo Han, Jong Bum Lee

Department of Chemical Engineering

University of Seoul

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Macroscopic nucleic acid-based structures have attracted much attention in biomedical fields. Here, we introduce a novel DNA-RNA hybridized membrane structureviaenzymatic dual polymerization. The membrane exhibited enhanced rigidity and functionality. Encoded with an aptamer, the membrane showed great potential as a collecting platform of tumor-derived exosomes without additional labeling.

Original language	English
Pages (from-to)	266-269
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	2
DOIs	https://doi.org/10.1039/d1cc05924f
State	Published - 7 Jan 2022

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abstract = "Macroscopic nucleic acid-based structures have attracted much attention in biomedical fields. Here, we introduce a novel DNA-RNA hybridized membrane structureviaenzymatic dual polymerization. The membrane exhibited enhanced rigidity and functionality. Encoded with an aptamer, the membrane showed great potential as a collecting platform of tumor-derived exosomes without additional labeling.",

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AU - Lee, Jong Bum

N1 - Publisher Copyright: © The Royal Society of Chemistry 2021.

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AB - Macroscopic nucleic acid-based structures have attracted much attention in biomedical fields. Here, we introduce a novel DNA-RNA hybridized membrane structureviaenzymatic dual polymerization. The membrane exhibited enhanced rigidity and functionality. Encoded with an aptamer, the membrane showed great potential as a collecting platform of tumor-derived exosomes without additional labeling.

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Construction of a two-dimensional DNA-RNA hybridized membrane for collecting tumor-derived exosomes

Abstract

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