Coupled feedback loops form dynamic motifs of cellular networks

Jeong Rae Kim, Yeoin Yoon, Kwang Hyun Cho

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


Cellular networks are composed of complicated interconnections among components, and some subnetworks of particular functioning are often identified as network motifs. Among such network motifs, feedback loops are thought to play important dynamical roles. Intriguingly, such feedback loops are very often found as a coupled structure in cellular circuits. Therefore, we integrated all the scattered information regarding the coupled feedbacks in various cellular circuits and investigated the dynamical role of each coupled structure. Finally, we discovered that coupled positive feedbacks enhance signal amplification and bistable characteristics; coupled negative feedbacks realize enhanced homeostasis; coupled positive and negative feedbacks enable reliable decision-making by properly modulating signal responses and effectively dealing with noise.

Original languageEnglish
Pages (from-to)359-365
Number of pages7
JournalBiophysical Journal
Issue number2
StatePublished - 15 Jan 2008


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