Cross-talk between Wnt/β-catenin and Hippo signaling pathways: A brief review

Minseong Kim, Eek Hoon Jho

Research output: Contribution to journalShort surveypeer-review

71 Scopus citations

Abstract

Balanced cell growth is crucial in animal development as well as tissue homeostasis. Concerted cross-regulation of multiple signaling pathways is essential for those purposes, and the dysregulation of signaling may lead to a variety of human diseases such as cancer. The time-honored Wnt/β-catenin and recently identified Hippo signaling pathways are evolutionarily conserved in both Drosophila and mammals, and are generally considered as having positive and negative roles in cell proliferation, respectively. While most mainstream regulators of the Wnt/β-catenin signaling pathway have been fairly well identified, the regulators of the Hippo pathway need to be more defined. The Hippo pathway controls organ size primarily by regulating cell contact inhibition. Recently, several crossregulations occurring between the Wnt/β-catenin and Hippo signaling pathways were determined through biochemical and genetic approaches. In the present mini-review, we mainly discuss the signal transduction mechanism of the Hippo signaling pathway, along with cross-talk between the regulators of the Wnt/β-catenin and Hippo signaling pathways.

Original languageEnglish
Pages (from-to)540-545
Number of pages6
JournalBMB Reports
Volume47
Issue number10
DOIs
StatePublished - 2014

Keywords

  • Crosstalk
  • Hippo signaling
  • Wnt signaling
  • YAP/TAZ
  • β-catenin

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