DNA aptamer-based carrier for loading proteins and enhancing the enzymatic activity

Jieun Kim; Dajeong Kim; Jong Bum Lee

doi:10.1039/c6ra25507h

DNA aptamer-based carrier for loading proteins and enhancing the enzymatic activity

Jieun Kim, Dajeong Kim, Jong Bum Lee

Department of Chemical Engineering

University of Seoul

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Here, we synthesized DNA microparticles comprised of thrombin binding aptamers via rolling circle amplification (RCA). These DNA aptamer particles could successfully load a number of thrombins and the complexes have shown improved thrombin activity. This new platform offers a protein loading and delivery system for medical applications.

Original language	English
Pages (from-to)	1643-1645
Number of pages	3
Journal	RSC Advances
Volume	7
Issue number	3
DOIs	https://doi.org/10.1039/c6ra25507h
State	Published - 2017

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10.1039/c6ra25507h

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title = "DNA aptamer-based carrier for loading proteins and enhancing the enzymatic activity",

abstract = "Here, we synthesized DNA microparticles comprised of thrombin binding aptamers via rolling circle amplification (RCA). These DNA aptamer particles could successfully load a number of thrombins and the complexes have shown improved thrombin activity. This new platform offers a protein loading and delivery system for medical applications.",

author = "Jieun Kim and Dajeong Kim and Lee, {Jong Bum}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c6ra25507h",

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T1 - DNA aptamer-based carrier for loading proteins and enhancing the enzymatic activity

AU - Kim, Jieun

AU - Kim, Dajeong

AU - Lee, Jong Bum

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - Here, we synthesized DNA microparticles comprised of thrombin binding aptamers via rolling circle amplification (RCA). These DNA aptamer particles could successfully load a number of thrombins and the complexes have shown improved thrombin activity. This new platform offers a protein loading and delivery system for medical applications.

AB - Here, we synthesized DNA microparticles comprised of thrombin binding aptamers via rolling circle amplification (RCA). These DNA aptamer particles could successfully load a number of thrombins and the complexes have shown improved thrombin activity. This new platform offers a protein loading and delivery system for medical applications.

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U2 - 10.1039/c6ra25507h

DO - 10.1039/c6ra25507h

M3 - Article

AN - SCOPUS:85009396493

SN - 2046-2069

VL - 7

SP - 1643

EP - 1645

JO - RSC Advances

JF - RSC Advances

IS - 3

ER -

DNA aptamer-based carrier for loading proteins and enhancing the enzymatic activity

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