DNA-based nanostructures for molecular sensing

Jong Bum Lee; Michael John Campolongo; Jason Samuel Kahn; Young Hoon Roh; Mark Richard Hartman; Dan Luo

doi:10.1039/b9nr00142e

DNA-based nanostructures for molecular sensing

Jong Bum Lee, Michael John Campolongo, Jason Samuel Kahn, Young Hoon Roh, Mark Richard Hartman, Dan Luo

Department of Chemical Engineering

Cornell University

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Nanotechnology has opened up new avenues towards ultra-sensitive, highly selective detection of biological molecules and toxic agents, as well as for therapeutic targeting and screening. Though the goals may seem singular, there is no universal method to identify or detect a molecular target. Each system is application-specific and must not only identify the target, but also transduce this interaction into a meaningful signal rapidly, reliably, and inexpensively. This review focuses on the current capabilities and future directions of DNA-based nanostructures in sensing and detection.

Original language	English
Pages (from-to)	188-197
Number of pages	10
Journal	Nanoscale
Volume	2
Issue number	2
DOIs	https://doi.org/10.1039/b9nr00142e
State	Published - 9 Feb 2010

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AB - Nanotechnology has opened up new avenues towards ultra-sensitive, highly selective detection of biological molecules and toxic agents, as well as for therapeutic targeting and screening. Though the goals may seem singular, there is no universal method to identify or detect a molecular target. Each system is application-specific and must not only identify the target, but also transduce this interaction into a meaningful signal rapidly, reliably, and inexpensively. This review focuses on the current capabilities and future directions of DNA-based nanostructures in sensing and detection.

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DNA-based nanostructures for molecular sensing

Abstract

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