DNAsomes: Multifunctional DNA-based nanocarriers

Young Hoon Roh; Jong Bum Lee; Pichamon Kiatwuthinon; Mark R. Hartman; Judy J. Cha; Soong Ho Um; David A. Muller; Dan Luo

doi:10.1002/smll.201000752

DNAsomes: Multifunctional DNA-based nanocarriers

Young Hoon Roh, Jong Bum Lee, Pichamon Kiatwuthinon, Mark R. Hartman, Judy J. Cha, Soong Ho Um, David A. Muller, Dan Luo

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Multifunctional DNAsomes: DNA-lipid amphiphiles self-assemble into novel "DNAsomes"a-liposome-like core-shell structures with subunits composed of branched DNA-lipid hybrid molecules. These DNAsomes can be precisely tuned over a wide range in terms of both size and surface charge. More importantly, DNAsome is a natural carrier of small interfering RNA (siRNA) due to DNA-RNA base-pairing, enabling efficient co-delivery of drugs and siRNA. The DNAsome represents a universal multifunctional drug vector for simultaneous delivery of drugs, tracer dyes, or antibodies, along with genes, siRNA, or antisense nucleic acids.

Original language	English
Pages (from-to)	74-78
Number of pages	5
Journal	Small
Volume	7
Issue number	1
DOIs	https://doi.org/10.1002/smll.201000752
State	Published - 3 Jan 2011

Keywords

DNA nanostructures
multidrug delivery
nanotechnology
self-assembly
siRNA

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10.1002/smll.201000752

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AU - Muller, David A.

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DNAsomes: Multifunctional DNA-based nanocarriers

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