DNAsomes: Multifunctional DNA-based nanocarriers

Young Hoon Roh, Jong Bum Lee, Pichamon Kiatwuthinon, Mark R. Hartman, Judy J. Cha, Soong Ho Um, David A. Muller, Dan Luo

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Multifunctional DNAsomes: DNA-lipid amphiphiles self-assemble into novel "DNAsomes"a-liposome-like core-shell structures with subunits composed of branched DNA-lipid hybrid molecules. These DNAsomes can be precisely tuned over a wide range in terms of both size and surface charge. More importantly, DNAsome is a natural carrier of small interfering RNA (siRNA) due to DNA-RNA base-pairing, enabling efficient co-delivery of drugs and siRNA. The DNAsome represents a universal multifunctional drug vector for simultaneous delivery of drugs, tracer dyes, or antibodies, along with genes, siRNA, or antisense nucleic acids.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalSmall
Volume7
Issue number1
DOIs
StatePublished - 3 Jan 2011

Keywords

  • DNA nanostructures
  • multidrug delivery
  • nanotechnology
  • self-assembly
  • siRNA

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