Efficient and stable radiolabeling of polycyclic aromatic hydrocarbon assemblies:: In vivo imaging of diesel exhaust particulates in mice

Chang Heon Lee, Ha Eun Shim, Lee Song, Hi Gyu Moon, Kyuhong Lee, Jung Eun Yang, Ha Yeon Song, Yong Jun Choi, Dae Seong Choi, Jongho Jeon

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

As a robust radioanalytical method for tracking carbonaceous particulates in vivo, polycyclic aromatic hydrocarbons from diesel exhaust were labeled with a radioactive-iodine-tagged pyrene analogue. Single-photon emission computed tomography and biodistribution studies showed high uptake and slow clearance of this matter in the respiratory system, which may underlie its severe toxicity.

Original languageEnglish
Pages (from-to)447-450
Number of pages4
JournalChemical Communications
Volume55
Issue number4
DOIs
StatePublished - 2019

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