Enhancing stability and bioavailability of sulforaphene in radish seed extracts using nanoemulsion made with high oleic sunflower oil

Tae Kyung Lee, Gihyun Hur, Jeongyoon Choi, Choongjin Ban, Jong Yea Kim, Hee Yang, Jung Han Yoon Park, Ki Won Lee, Jong Hun Kim

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of nanoemulsions on the stability and bioavailability of sulforaphene (SFEN) in radish seed extract (RSE) was investigated. Four types of oil were used as lipid ingredients of the nanoemulsions: soybean, high oleic acid sunflower, coconut, and hydrogenated palm oils. SFEN in RSE nanoemulsions showed greater stability to temperature, acid, and alkaline conditions than SFEN in RSE suspended in water (RSE-S). Particularly under alkaline conditions, the half-life of SFEN in the nanoemulsion with high oleic sunflower oil (RSE-HOSO) was 8 times longer than that of RSE-S. Furthermore, in the pharmacokinetics study, it was observed that AUC0–8 increased and oral clearance (CL/F) decreased significantly in rats orally administered RSE-HOSO compared with RSE-S (p < 0.05). This study indicates that the type of oil used in nanoemulsions affects the stability and bioavailability of SFEN in RSE. These results may provide a guideline for the development of functional foods containing RSE.

Original languageEnglish
Pages (from-to)1269-1279
Number of pages11
JournalFood Science and Biotechnology
Volume32
Issue number9
DOIs
StatePublished - Aug 2023

Keywords

  • Nanoemulsion
  • Pharmacokinetics
  • Radish seeds
  • Storage stability
  • Vegetable oils

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