Enhancing stability and bioavailability of sulforaphene in radish seed extracts using nanoemulsion made with high oleic sunflower oil

Tae Kyung Lee; Gihyun Hur; Jeongyoon Choi; Choongjin Ban; Jong Yea Kim; Hee Yang; Jung Han Yoon Park; Ki Won Lee; Jong Hun Kim

doi:10.1007/s10068-023-01304-2

Enhancing stability and bioavailability of sulforaphene in radish seed extracts using nanoemulsion made with high oleic sunflower oil

Tae Kyung Lee, Gihyun Hur, Jeongyoon Choi, Choongjin Ban, Jong Yea Kim, Hee Yang, Jung Han Yoon Park, Ki Won Lee, Jong Hun Kim

Department of Environmental Horticulture

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effect of nanoemulsions on the stability and bioavailability of sulforaphene (SFEN) in radish seed extract (RSE) was investigated. Four types of oil were used as lipid ingredients of the nanoemulsions: soybean, high oleic acid sunflower, coconut, and hydrogenated palm oils. SFEN in RSE nanoemulsions showed greater stability to temperature, acid, and alkaline conditions than SFEN in RSE suspended in water (RSE-S). Particularly under alkaline conditions, the half-life of SFEN in the nanoemulsion with high oleic sunflower oil (RSE-HOSO) was 8 times longer than that of RSE-S. Furthermore, in the pharmacokinetics study, it was observed that AUC_0–8 increased and oral clearance (CL/F) decreased significantly in rats orally administered RSE-HOSO compared with RSE-S (p < 0.05). This study indicates that the type of oil used in nanoemulsions affects the stability and bioavailability of SFEN in RSE. These results may provide a guideline for the development of functional foods containing RSE.

Original language	English
Pages (from-to)	1269-1279
Number of pages	11
Journal	Food Science and Biotechnology
Volume	32
Issue number	9
DOIs	https://doi.org/10.1007/s10068-023-01304-2
State	Published - Aug 2023

Keywords

Nanoemulsion
Pharmacokinetics
Radish seeds
Storage stability
Vegetable oils

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@article{361f98dd63a34d039a0e89f8303f0aa2,

title = "Enhancing stability and bioavailability of sulforaphene in radish seed extracts using nanoemulsion made with high oleic sunflower oil",

abstract = "The effect of nanoemulsions on the stability and bioavailability of sulforaphene (SFEN) in radish seed extract (RSE) was investigated. Four types of oil were used as lipid ingredients of the nanoemulsions: soybean, high oleic acid sunflower, coconut, and hydrogenated palm oils. SFEN in RSE nanoemulsions showed greater stability to temperature, acid, and alkaline conditions than SFEN in RSE suspended in water (RSE-S). Particularly under alkaline conditions, the half-life of SFEN in the nanoemulsion with high oleic sunflower oil (RSE-HOSO) was 8 times longer than that of RSE-S. Furthermore, in the pharmacokinetics study, it was observed that AUC0–8 increased and oral clearance (CL/F) decreased significantly in rats orally administered RSE-HOSO compared with RSE-S (p < 0.05). This study indicates that the type of oil used in nanoemulsions affects the stability and bioavailability of SFEN in RSE. These results may provide a guideline for the development of functional foods containing RSE.",

keywords = "Nanoemulsion, Pharmacokinetics, Radish seeds, Storage stability, Vegetable oils",

author = "Lee, {Tae Kyung} and Gihyun Hur and Jeongyoon Choi and Choongjin Ban and Kim, {Jong Yea} and Hee Yang and Park, {Jung Han Yoon} and Lee, {Ki Won} and Kim, {Jong Hun}",

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year = "2023",

month = aug,

doi = "10.1007/s10068-023-01304-2",

language = "English",

volume = "32",

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T1 - Enhancing stability and bioavailability of sulforaphene in radish seed extracts using nanoemulsion made with high oleic sunflower oil

AU - Lee, Tae Kyung

AU - Hur, Gihyun

AU - Choi, Jeongyoon

AU - Ban, Choongjin

AU - Kim, Jong Yea

AU - Yang, Hee

AU - Park, Jung Han Yoon

AU - Lee, Ki Won

AU - Kim, Jong Hun

PY - 2023/8

Y1 - 2023/8

N2 - The effect of nanoemulsions on the stability and bioavailability of sulforaphene (SFEN) in radish seed extract (RSE) was investigated. Four types of oil were used as lipid ingredients of the nanoemulsions: soybean, high oleic acid sunflower, coconut, and hydrogenated palm oils. SFEN in RSE nanoemulsions showed greater stability to temperature, acid, and alkaline conditions than SFEN in RSE suspended in water (RSE-S). Particularly under alkaline conditions, the half-life of SFEN in the nanoemulsion with high oleic sunflower oil (RSE-HOSO) was 8 times longer than that of RSE-S. Furthermore, in the pharmacokinetics study, it was observed that AUC0–8 increased and oral clearance (CL/F) decreased significantly in rats orally administered RSE-HOSO compared with RSE-S (p < 0.05). This study indicates that the type of oil used in nanoemulsions affects the stability and bioavailability of SFEN in RSE. These results may provide a guideline for the development of functional foods containing RSE.

AB - The effect of nanoemulsions on the stability and bioavailability of sulforaphene (SFEN) in radish seed extract (RSE) was investigated. Four types of oil were used as lipid ingredients of the nanoemulsions: soybean, high oleic acid sunflower, coconut, and hydrogenated palm oils. SFEN in RSE nanoemulsions showed greater stability to temperature, acid, and alkaline conditions than SFEN in RSE suspended in water (RSE-S). Particularly under alkaline conditions, the half-life of SFEN in the nanoemulsion with high oleic sunflower oil (RSE-HOSO) was 8 times longer than that of RSE-S. Furthermore, in the pharmacokinetics study, it was observed that AUC0–8 increased and oral clearance (CL/F) decreased significantly in rats orally administered RSE-HOSO compared with RSE-S (p < 0.05). This study indicates that the type of oil used in nanoemulsions affects the stability and bioavailability of SFEN in RSE. These results may provide a guideline for the development of functional foods containing RSE.

KW - Nanoemulsion

KW - Pharmacokinetics

KW - Radish seeds

KW - Storage stability

KW - Vegetable oils

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U2 - 10.1007/s10068-023-01304-2

DO - 10.1007/s10068-023-01304-2

M3 - Article

AN - SCOPUS:85151505164

SN - 1226-7708

VL - 32

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EP - 1279

JO - Food Science and Biotechnology

JF - Food Science and Biotechnology

IS - 9

ER -

Enhancing stability and bioavailability of sulforaphene in radish seed extracts using nanoemulsion made with high oleic sunflower oil

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