Enzymatically Produced miR34a Nanoparticles for Enhanced Antiproliferation Activity

Hyejin Kim, Eunju Lee, Yoon Young Kang, Jihyun Song, Hyejung Mok, Jong Bum Lee

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Among a range of functional forms of RNA, microRNAs (miRNAs) have held a great promise for their natural ability to influence cellular behavior by regulating gene expression. In particular, it is revealed that miR34a has a function as a tumor suppressor by regulating silent information regulator 1 expression, causing antiproliferation of tumor. To utilize functional miR34a as an effective cancer therapeutics, an enzymatic approach to synthesize miR34a nanoparticles is adapted. The enzymatically self-assembled miR34a nanoparticles have a high cargo capacity and a suitable size for cellular uptake. Indeed, the miR34a nanoparticles are delivered successfully to PC3 cells, human prostate cancer cells, and suppress proliferation and migration of those cells. These results suggest that the enzymatically produced miR34a nanoparticles can function as an effective tumor suppressor. Furthermore, it is expected that the enzymatic synthesis of miRNA nanoparticles can be adapted universally for delivery of other functional miRNAs as well.

Original languageEnglish
Article number1700158
JournalAdvanced Biosystems
Issue number2
StatePublished - 1 Feb 2018


  • RNA nanoparticles
  • cancer therapeutics
  • enzymatic synthesis
  • miRNA delivery


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