Epigenetic Regulations in Mammalian Cells: Roles and Profiling Techniques

Uijin Kim, Dong Sung Lee

Research output: Contribution to journalShort surveypeer-review

13 Scopus citations

Abstract

The genome is almost identical in all the cells of the body. However, the functions and morphologies of each cell are different, and the factors that determine them are the genes and proteins expressed in the cells. Over the past decades, studies on epigenetic information, such as DNA methylation, histone modifications, chromatin accessibility, and chromatin conformation have shown that these properties play a fundamental role in gene regulation. Furthermore, various diseases such as cancer have been found to be associated with epigenetic mechanisms. In this study, we summarized the biological properties of epigenetics and single-cell epigenomic profiling techniques, and discussed future challenges in the field of epigenetics.

Original languageEnglish
Pages (from-to)86-98
Number of pages13
JournalMolecules and Cells
Volume46
Issue number2
DOIs
StatePublished - 28 Feb 2023

Keywords

  • 3D chromatin structure
  • DNA methylation
  • RNA modification
  • histone modification
  • single-cell epigenomics

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