TY - JOUR
T1 - Epigenetic Regulations in Mammalian Cells
T2 - Roles and Profiling Techniques
AU - Kim, Uijin
AU - Lee, Dong Sung
N1 - Publisher Copyright:
© The Korean Society for Molecular and Cellular Biology.
PY - 2023/2/28
Y1 - 2023/2/28
N2 - The genome is almost identical in all the cells of the body. However, the functions and morphologies of each cell are different, and the factors that determine them are the genes and proteins expressed in the cells. Over the past decades, studies on epigenetic information, such as DNA methylation, histone modifications, chromatin accessibility, and chromatin conformation have shown that these properties play a fundamental role in gene regulation. Furthermore, various diseases such as cancer have been found to be associated with epigenetic mechanisms. In this study, we summarized the biological properties of epigenetics and single-cell epigenomic profiling techniques, and discussed future challenges in the field of epigenetics.
AB - The genome is almost identical in all the cells of the body. However, the functions and morphologies of each cell are different, and the factors that determine them are the genes and proteins expressed in the cells. Over the past decades, studies on epigenetic information, such as DNA methylation, histone modifications, chromatin accessibility, and chromatin conformation have shown that these properties play a fundamental role in gene regulation. Furthermore, various diseases such as cancer have been found to be associated with epigenetic mechanisms. In this study, we summarized the biological properties of epigenetics and single-cell epigenomic profiling techniques, and discussed future challenges in the field of epigenetics.
KW - 3D chromatin structure
KW - DNA methylation
KW - RNA modification
KW - histone modification
KW - single-cell epigenomics
UR - http://www.scopus.com/inward/record.url?scp=85149427877&partnerID=8YFLogxK
U2 - 10.14348/molcells.2023.0013
DO - 10.14348/molcells.2023.0013
M3 - Short survey
C2 - 36859473
AN - SCOPUS:85149427877
SN - 1016-8478
VL - 46
SP - 86
EP - 98
JO - Molecules and Cells
JF - Molecules and Cells
IS - 2
ER -