Gold and silver plasmonic nanoprobes trace the positions of histone codes

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We visualized the distribution of heterochromatin in a single nucleus using plasmonic nanoparticle-conjugated H3K9me3 and H3K27me3 antibodies. Due to distance-dependent plasmonic coupling effects between nanoprobes, their scattering spectra shift to longer wavelengths as the distance between heterochromatin histone markers reduced during oncogene-induced senescence (OIS). These observations were supported by simulating scattering profiles based on considerations of particle numbers, interparticle distances, and the spatial arrangements of plasmonic nanoprobes. Using this plasmon-based colourimetric imaging, we estimated changes in distances between H3K9me3 and H3K27me3 during the formation of senescence-associated heterochromatin foci in OIS cells.

Original languageEnglish
Pages (from-to)111-112
Number of pages2
JournalBMB Reports
Issue number3
StatePublished - 2022


  • Heterochromatin
  • Histone modification
  • Oncogene-induced senescence
  • Plasmonic coupling effect
  • Plasmonic nanoparticles
  • Singlecell imaging


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