Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

Jinyoung Kang; Jaemoon Yang; Jaewon Lee; Seung Jae Oh; Seyoung Moon; Hong Jae Lee; Sang Cheon Lee; Joo Hiuk Son; Donghyun Kim; Kwangyeol Lee; Jin Suck Suh; Yong Min Huh; Seungjoo Haam

doi:10.1039/b822835c

Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

Jinyoung Kang, Jaemoon Yang, Jaewon Lee, Seung Jae Oh, Seyoung Moon, Hong Jae Lee, Sang Cheon Lee, Joo Hiuk Son, Donghyun Kim, Kwangyeol Lee, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Department of Physics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux ^® and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.

Original language	English
Pages (from-to)	2902-2905
Number of pages	4
Journal	Journal of Materials Chemistry
Volume	19
Issue number	19
DOIs	https://doi.org/10.1039/b822835c
State	Published - 2009

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10.1039/b822835c

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title = "Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer",

abstract = "We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux {\textregistered} and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.",

author = "Jinyoung Kang and Jaemoon Yang and Jaewon Lee and Oh, {Seung Jae} and Seyoung Moon and Lee, {Hong Jae} and Lee, {Sang Cheon} and Son, {Joo Hiuk} and Donghyun Kim and Kwangyeol Lee and Suh, {Jin Suck} and Huh, {Yong Min} and Seungjoo Haam",

year = "2009",

doi = "10.1039/b822835c",

language = "English",

volume = "19",

pages = "2902--2905",

journal = "Journal of Materials Chemistry",

issn = "0959-9428",

publisher = "Royal Society of Chemistry",

number = "19",

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TY - JOUR

T1 - Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

AU - Kang, Jinyoung

AU - Yang, Jaemoon

AU - Lee, Jaewon

AU - Oh, Seung Jae

AU - Moon, Seyoung

AU - Lee, Hong Jae

AU - Lee, Sang Cheon

AU - Son, Joo Hiuk

AU - Kim, Donghyun

AU - Lee, Kwangyeol

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Haam, Seungjoo

PY - 2009

Y1 - 2009

N2 - We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux ® and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.

AB - We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux ® and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.

UR - http://www.scopus.com/inward/record.url?scp=65549152800&partnerID=8YFLogxK

U2 - 10.1039/b822835c

DO - 10.1039/b822835c

M3 - Article

AN - SCOPUS:65549152800

SN - 0959-9428

VL - 19

SP - 2902

EP - 2905

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 19

ER -

Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

Abstract

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