Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

Jinyoung Kang; Jaemoon Yang; Jaewon Lee; Seung Jae Oh; Seyoung Moon; Hong Jae Lee; Sang Cheon Lee; Joo Hiuk Son; Donghyun Kim; Kwangyeol Lee; Jin Suck Suh; Yong Min Huh; Seungjoo Haam

doi:10.1039/b822835c

Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

Jinyoung Kang
, Jaemoon Yang
, Jaewon Lee
, Seung Jae Oh
, Seyoung Moon
, Hong Jae Lee
, Sang Cheon Lee
, Joo Hiuk Son
, Donghyun Kim
, Kwangyeol Lee
, Jin Suck Suh
, Yong Min Huh
, Seungjoo Haam

Department of Physics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux ^® and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.

Original language	English
Pages (from-to)	2902-2905
Number of pages	4
Journal	Journal of Materials Chemistry
Volume	19
Issue number	19
DOIs	https://doi.org/10.1039/b822835c
State	Published - 2009

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10.1039/b822835c

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title = "Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer",

abstract = "We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux {\textregistered} and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.",

author = "Jinyoung Kang and Jaemoon Yang and Jaewon Lee and Oh, \{Seung Jae\} and Seyoung Moon and Lee, \{Hong Jae\} and Lee, \{Sang Cheon\} and Son, \{Joo Hiuk\} and Donghyun Kim and Kwangyeol Lee and Suh, \{Jin Suck\} and Huh, \{Yong Min\} and Seungjoo Haam",

year = "2009",

doi = "10.1039/b822835c",

language = "English",

volume = "19",

pages = "2902--2905",

journal = "Journal of Materials Chemistry",

issn = "0959-9428",

publisher = "Royal Society of Chemistry",

number = "19",

}

TY - JOUR

T1 - Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

AU - Kang, Jinyoung

AU - Yang, Jaemoon

AU - Lee, Jaewon

AU - Oh, Seung Jae

AU - Moon, Seyoung

AU - Lee, Hong Jae

AU - Lee, Sang Cheon

AU - Son, Joo Hiuk

AU - Kim, Donghyun

AU - Lee, Kwangyeol

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Haam, Seungjoo

PY - 2009

Y1 - 2009

N2 - We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux ® and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.

AB - We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux ® and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.

UR - https://www.scopus.com/pages/publications/65549152800

U2 - 10.1039/b822835c

DO - 10.1039/b822835c

M3 - Article

AN - SCOPUS:65549152800

SN - 0959-9428

VL - 19

SP - 2902

EP - 2905

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 19

ER -

Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

Abstract

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