Highly Sensitive and Selective Detection of Steroid Hormones Using Terahertz Molecule-Specific Sensors

Sang Hun Lee, Donggeun Lee, Man Ho Choi, Joo Hiuk Son, Minah Seo

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Discrimination and quantification of trace amounts of steroid hormones in biological specimens are needed to elucidate their changing expression because their biological functions are responsible for the development and prevention of endocrine disorders. Although mass-spectrometry-based assays are most commonly recommended, development of a new type of highly sensitive and selective detection methods in clinical practices is needed. Here, we introduce a label-free type of terahertz molecule sensor capable of sensing and identifying progesterone and 17α-OH-progesterone selectively. Nanoslot-array-based sensing chips were used as launching pads for absorption cross-section enhancement of molecules at a reliable terahertz frequency. With use of nanoslots with resonances at 1.17 THz corresponding to intrinsic THz absorption resonance mode for progesterone and at 1.51 THz for 17α-OH-progesterone, respectively, each steroid shows prominent transmittance change in terms of its amount. In particular, the sensing performance has been much improved by controlling evaporation speed, in turn resulting in an efficient, homogeneous distribution of the molecules onto a sensing hot spot.

Original languageEnglish
Pages (from-to)6844-6849
Number of pages6
JournalAnalytical Chemistry
Volume91
Issue number10
DOIs
StatePublished - 21 May 2019

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