Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells

Young Kwon Park; Bongju Park; Seongyeol Lee; Kang Choi; Yunwon Moon; Hyunsung Park

doi:10.1074/jbc.M113.500835

Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells

Young Kwon Park, Bongju Park, Seongyeol Lee, Kang Choi, Yunwon Moon, Hyunsung Park

Department of Life Science

University of Seoul

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Background: In obesity, enlarged adipocytes become hypoxic, which inhibits adipocyte differentiation. Results: Hypoxia induces the expression of Wnt1 and Wnt10b in both human and mouse adipogenic cells in a hypoxiainducible factor (HIF)-2-dependent manner. Conclusion: Hypoxia enhances the secretion of Wnt ligands, which trigger Wnt signaling in the neighboring cells. Significance: Wnt10b is a novel HIF-2-specific target gene and a paracrine factor in hypoxia.

Original language	English
Pages (from-to)	26311-26322
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M113.500835
State	Published - 6 Sep 2013

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10.1074/jbc.M113.500835

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title = "Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells",

abstract = "Background: In obesity, enlarged adipocytes become hypoxic, which inhibits adipocyte differentiation. Results: Hypoxia induces the expression of Wnt1 and Wnt10b in both human and mouse adipogenic cells in a hypoxiainducible factor (HIF)-2-dependent manner. Conclusion: Hypoxia enhances the secretion of Wnt ligands, which trigger Wnt signaling in the neighboring cells. Significance: Wnt10b is a novel HIF-2-specific target gene and a paracrine factor in hypoxia.",

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AU - Park, Young Kwon

AU - Park, Bongju

AU - Lee, Seongyeol

AU - Choi, Kang

AU - Moon, Yunwon

AU - Park, Hyunsung

PY - 2013/9/6

Y1 - 2013/9/6

N2 - Background: In obesity, enlarged adipocytes become hypoxic, which inhibits adipocyte differentiation. Results: Hypoxia induces the expression of Wnt1 and Wnt10b in both human and mouse adipogenic cells in a hypoxiainducible factor (HIF)-2-dependent manner. Conclusion: Hypoxia enhances the secretion of Wnt ligands, which trigger Wnt signaling in the neighboring cells. Significance: Wnt10b is a novel HIF-2-specific target gene and a paracrine factor in hypoxia.

AB - Background: In obesity, enlarged adipocytes become hypoxic, which inhibits adipocyte differentiation. Results: Hypoxia induces the expression of Wnt1 and Wnt10b in both human and mouse adipogenic cells in a hypoxiainducible factor (HIF)-2-dependent manner. Conclusion: Hypoxia enhances the secretion of Wnt ligands, which trigger Wnt signaling in the neighboring cells. Significance: Wnt10b is a novel HIF-2-specific target gene and a paracrine factor in hypoxia.

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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ER -

Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells

Abstract

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