Abstract
Background: In obesity, enlarged adipocytes become hypoxic, which inhibits adipocyte differentiation. Results: Hypoxia induces the expression of Wnt1 and Wnt10b in both human and mouse adipogenic cells in a hypoxiainducible factor (HIF)-2-dependent manner. Conclusion: Hypoxia enhances the secretion of Wnt ligands, which trigger Wnt signaling in the neighboring cells. Significance: Wnt10b is a novel HIF-2-specific target gene and a paracrine factor in hypoxia.
| Original language | English |
|---|---|
| Pages (from-to) | 26311-26322 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 36 |
| DOIs | |
| State | Published - 6 Sep 2013 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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