Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells

Young Kwon Park; Bongju Park; Seongyeol Lee; Kang Choi; Yunwon Moon; Hyunsung Park

doi:10.1074/jbc.M113.500835

Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells

Young Kwon Park, Bongju Park, Seongyeol Lee, Kang Choi, Yunwon Moon, Hyunsung Park

University of Seoul

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Background: In obesity, enlarged adipocytes become hypoxic, which inhibits adipocyte differentiation. Results: Hypoxia induces the expression of Wnt1 and Wnt10b in both human and mouse adipogenic cells in a hypoxiainducible factor (HIF)-2-dependent manner. Conclusion: Hypoxia enhances the secretion of Wnt ligands, which trigger Wnt signaling in the neighboring cells. Significance: Wnt10b is a novel HIF-2-specific target gene and a paracrine factor in hypoxia.

Original language	English
Pages (from-to)	26311-26322
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M113.500835
State	Published - 6 Sep 2013

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10.1074/jbc.M113.500835

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title = "Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells",

abstract = "Background: In obesity, enlarged adipocytes become hypoxic, which inhibits adipocyte differentiation. Results: Hypoxia induces the expression of Wnt1 and Wnt10b in both human and mouse adipogenic cells in a hypoxiainducible factor (HIF)-2-dependent manner. Conclusion: Hypoxia enhances the secretion of Wnt ligands, which trigger Wnt signaling in the neighboring cells. Significance: Wnt10b is a novel HIF-2-specific target gene and a paracrine factor in hypoxia.",

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T1 - Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells

AU - Park, Young Kwon

AU - Park, Bongju

AU - Lee, Seongyeol

AU - Choi, Kang

AU - Moon, Yunwon

AU - Park, Hyunsung

PY - 2013/9/6

Y1 - 2013/9/6

N2 - Background: In obesity, enlarged adipocytes become hypoxic, which inhibits adipocyte differentiation. Results: Hypoxia induces the expression of Wnt1 and Wnt10b in both human and mouse adipogenic cells in a hypoxiainducible factor (HIF)-2-dependent manner. Conclusion: Hypoxia enhances the secretion of Wnt ligands, which trigger Wnt signaling in the neighboring cells. Significance: Wnt10b is a novel HIF-2-specific target gene and a paracrine factor in hypoxia.

AB - Background: In obesity, enlarged adipocytes become hypoxic, which inhibits adipocyte differentiation. Results: Hypoxia induces the expression of Wnt1 and Wnt10b in both human and mouse adipogenic cells in a hypoxiainducible factor (HIF)-2-dependent manner. Conclusion: Hypoxia enhances the secretion of Wnt ligands, which trigger Wnt signaling in the neighboring cells. Significance: Wnt10b is a novel HIF-2-specific target gene and a paracrine factor in hypoxia.

UR - https://www.scopus.com/pages/publications/84883720377

U2 - 10.1074/jbc.M113.500835

DO - 10.1074/jbc.M113.500835

M3 - Article

C2 - 23900840

AN - SCOPUS:84883720377

SN - 0021-9258

VL - 288

SP - 26311

EP - 26322

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 36

ER -

Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells

Abstract

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