Improving flavonoid bioaccessibility using an edible oil-based lipid nanoparticle for oral delivery

Choongjin Ban, So Jeong Park, Seokwon Lim, Seung Jun Choi, Young Jin Choi

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


To enhance the oral bioaccessibility of flavonoids, including quercetin, naringenin, and hesperetin, we prepared an edible oil-based lipid nanoparticle (LNP) system. Flavonoid-loaded LNPs were similar to the blank LNP in physicochemical characteristics (z average <154.8 nm, polydispersity index <0.17, and Χ potential < -40.8 mV), and their entrapment efficiency was >81% at 0.3 wt % flavonoid concentration of the lipid phase. In the simulated digestion assay (mouth, stomach, and small intestine), LNPs were hydrolyzed under small intestine conditions and protected successfully incorporated flavonoids (≥94%). Moreover, the relative bioaccessibility of flavonoids was >71%, which was otherwise <15%, although flavonoids were released rapidly from LNPs into the medium. In conclusion, since the flavonoids incorporated in LNPs were preserved well during oral digestion and had improved bioaccessibility, the designed LNP system may serve as an encapsulation strategy to enhance the bioavailability of nonbioaccessible nutraceuticals in foods.

Original languageEnglish
Pages (from-to)5266-5272
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Issue number21
StatePublished - 3 Jun 2015


  • bioaccessibility
  • flavonoid
  • lipid nanoparticle
  • protectibility
  • simulated digestion


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