Inverse Association Between Statin Use and Overall Cancer Incidence in Individuals With Hypercholesterolemia, Based on the Korean Health Insurance Service Between 2002 and 2015

Joungyoun Kim, Na Young You, Jae Woo Lee, Yesul Kim, Yong Whan Kim, Hee Taik Kang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The Korean National Health Insurance Service provided the Health Screening Cohort Database. To investigate the cumulative effect of statins on cancer development, we defined statin users as those who used statins during 2002 to 2003 at baseline. Statin users were divided into high and low users. Statin nonusers were defined as individuals who had never used statins during the entire period of 2002 to 2015, despite having hypercholesterolemia. In total, 17 737 statin users and 13 412 statin nonusers were included in the final analyses. The median follow-up duration was 12.6 years. Compared with nonusers, the hazard ratios (95% confidential intervals) for any cancer incidence of low users and high users were 1.047 (0.941-1.164) and 0.663 (0.589-0.747) in men and 1.057 (0.938-1.190) and 0.592 (0.517-0.678) in women, respectively, after fully adjusting for possible confounding factors. An inverse association between statin use and any cancer incidence in individuals with hypercholesterolemia was observed.

Original languageEnglish
Pages (from-to)136-146
Number of pages11
JournalAsia-Pacific Journal of Public Health
Volume31
Issue number2
DOIs
StatePublished - 1 Mar 2019

Keywords

  • HMG-CoA reductase inhibitors
  • hypercholesterolemia
  • incidence
  • malignant neoplasms
  • mevalonate pathway

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