Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation

Yong Ryoul Yang; Seungju Song; Hongik Hwang; Jung Hoon Jung; Su Jeong Kim; Sora Yoon; Jin Hoe Hur; Jae Il Park; Cheol Lee; Dougu Nam; Young Kyo Seo; Joung Hun Kim; Hyewhon Rhim; Pann Ghill Suh

doi:10.1038/srep44921

Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation

Yong Ryoul Yang, Seungju Song, Hongik Hwang, Jung Hoon Jung, Su Jeong Kim, Sora Yoon, Jin Hoe Hur, Jae Il Park, Cheol Lee, Dougu Nam, Young Kyo Seo, Joung Hun Kim, Hyewhon Rhim, Pann Ghill Suh

Department of Life Science

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga^+/- mice which have an increased level of O-GlcNAcylation, and found that Oga^+/- mice exhibited impaired spatial learning and memory. Consistent with this result, Oga^+/- mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-O-GlcNAcylation in learning and memory.

Original language	English
Article number	44921
Journal	Scientific Reports
Volume	7
DOIs	https://doi.org/10.1038/srep44921
State	Published - 3 Apr 2017

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title = "Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation",

abstract = "O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga+/- mice which have an increased level of O-GlcNAcylation, and found that Oga+/- mice exhibited impaired spatial learning and memory. Consistent with this result, Oga+/- mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-O-GlcNAcylation in learning and memory.",

author = "Yang, {Yong Ryoul} and Seungju Song and Hongik Hwang and Jung, {Jung Hoon} and Kim, {Su Jeong} and Sora Yoon and Hur, {Jin Hoe} and Park, {Jae Il} and Cheol Lee and Dougu Nam and Seo, {Young Kyo} and Kim, {Joung Hun} and Hyewhon Rhim and Suh, {Pann Ghill}",

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doi = "10.1038/srep44921",

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AU - Yang, Yong Ryoul

AU - Song, Seungju

AU - Hwang, Hongik

AU - Jung, Jung Hoon

AU - Kim, Su Jeong

AU - Yoon, Sora

AU - Hur, Jin Hoe

AU - Park, Jae Il

AU - Lee, Cheol

AU - Nam, Dougu

AU - Seo, Young Kyo

AU - Kim, Joung Hun

AU - Rhim, Hyewhon

AU - Suh, Pann Ghill

PY - 2017/4/3

Y1 - 2017/4/3

N2 - O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga+/- mice which have an increased level of O-GlcNAcylation, and found that Oga+/- mice exhibited impaired spatial learning and memory. Consistent with this result, Oga+/- mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-O-GlcNAcylation in learning and memory.

AB - O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga+/- mice which have an increased level of O-GlcNAcylation, and found that Oga+/- mice exhibited impaired spatial learning and memory. Consistent with this result, Oga+/- mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-O-GlcNAcylation in learning and memory.

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JO - Scientific Reports

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Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation

Abstract

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