TY - JOUR
T1 - Multifunctional nanoarchitectures from DNA-based ABC monomers
AU - Lee, Jong B.
AU - Roh, Young H.
AU - Um, Soong Ho
AU - Funabashi, Hisakage
AU - Cheng, Wenlong
AU - Cha, Judy J.
AU - Kiatwuthinon, Pichamon
AU - Muller, David A.
AU - Luo, Dan
PY - 2009/7
Y1 - 2009/7
N2 - The ability to attach different functional moieties to a molecular building block could lead to applications in nanoelectronics, nanophotonics, intelligent sensing and drug delivery. The building unit needs to be both multivalent and anisotropic, and although many anisotropic building blocks have been created, these have not been universally applicable. Recently, DNA has been used to generate various nanostructures or hybrid systems, and as a generic building block for various applications. Here, we report the creation of anisotropic, branched and crosslinkable building blocks (ABC monomers) from which multifunctional nanoarchitectures have been assembled. In particular, we demonstrate a target-driven polymerization process in which polymers are generated only in the presence of a specific DNA molecule, leading to highly sensitive pathogen detection. Using this monomer system, we have also designed a biocompatible nanovector that delivers both drugs and tracers simultaneously. Our approach provides a general yet versatile route towards the creation of a range of multifunctional nanoarchitectures.
AB - The ability to attach different functional moieties to a molecular building block could lead to applications in nanoelectronics, nanophotonics, intelligent sensing and drug delivery. The building unit needs to be both multivalent and anisotropic, and although many anisotropic building blocks have been created, these have not been universally applicable. Recently, DNA has been used to generate various nanostructures or hybrid systems, and as a generic building block for various applications. Here, we report the creation of anisotropic, branched and crosslinkable building blocks (ABC monomers) from which multifunctional nanoarchitectures have been assembled. In particular, we demonstrate a target-driven polymerization process in which polymers are generated only in the presence of a specific DNA molecule, leading to highly sensitive pathogen detection. Using this monomer system, we have also designed a biocompatible nanovector that delivers both drugs and tracers simultaneously. Our approach provides a general yet versatile route towards the creation of a range of multifunctional nanoarchitectures.
UR - http://www.scopus.com/inward/record.url?scp=67651222407&partnerID=8YFLogxK
U2 - 10.1038/nnano.2009.93
DO - 10.1038/nnano.2009.93
M3 - Article
C2 - 19581895
AN - SCOPUS:67651222407
SN - 1748-3387
VL - 4
SP - 430
EP - 436
JO - Nature Nanotechnology
JF - Nature Nanotechnology
IS - 7
ER -