Multimeric RNAs for efficient RNA-based therapeutics and vaccines

Dajeong Kim, Sangwoo Han, Yoonbin Ji, Sunghyun Moon, Hyangsu Nam, Jong Bum Lee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


There has been a growing interest in RNA therapeutics globally, and much progress has been made in this area, which has been further accelerated by the clinical applications of RNA-based vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Following these successful clinical trials, various technologies have been developed to improve the efficacy of RNA-based drugs. Multimerization of RNA therapeutics is one of the most attractive approaches to ensure high stability, high efficacy, and prolonged action of RNA-based drugs. In this review, we offer an overview of the representative approaches for generating repetitive functional RNAs by chemical conjugation, structural self-assembly, enzymatic elongation, and self-amplification. The therapeutic and vaccine applications of engineered multimeric RNAs in various diseases have also been summarized. By outlining the current status of multimeric RNAs, the potential of multimeric RNA as a promising treatment strategy is highlighted.

Original languageEnglish
Pages (from-to)770-785
Number of pages16
JournalJournal of Controlled Release
StatePublished - May 2022


  • Multimeric RNA
  • RNA elongation
  • RNA nanostructure
  • RNA therapeutics
  • Rolling circle transcription
  • Self-amplifying RNA
  • mRNA vaccines


Dive into the research topics of 'Multimeric RNAs for efficient RNA-based therapeutics and vaccines'. Together they form a unique fingerprint.

Cite this