Multimodal Golden DNA Superstructures (GDSs) for Highly Efficient Photothermal Immunotherapy

Dajeong Kim, So Jung Kim, Jaepil Jeong, Sangwoo Han, Hyejin Kim, Seungki Lee, Inhee Choi, Jinkee Hong, Jun O. Jin, Jong Bum Lee

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

DNA-templated metallization has emerged as an efficient strategy for creating nanoscale-metal DNA hybrid structures with a desirable conformation and function. Despite the potential of DNA-metal hybrids, their use as combinatory therapeutic agents has rarely been examined. Herein, we present a simple approach for fabricating a multipurpose DNA superstructure that serves as an efficient photoimmunotherapy agent. Specifically, we adsorb and locally concentrate Au ions onto DNA superstructures through induced local reduction, resulting in the formation of Au nanoclusters. The mechanical and optical properties of these metallic nanoclusters can be rationally controlled by their conformations and metal ions. The resulting golden DNA superstructures (GDSs) exhibit significant photothermal effects that induce cancer cell apoptosis. When sequence-specific immunostimulatory effects of DNA are combined, GDSs provide a synergistic effect to eradicate cancer and inhibit metastasis, demonstrating potential as a combinatory therapeutic agent for tumor treatment. Altogether, the DNA superstructure-templated metal casting system offers promising materials for future biomedical applications.

Original languageEnglish
Pages (from-to)1744-1755
Number of pages12
JournalACS Nano
Volume18
Issue number2
DOIs
StatePublished - 16 Jan 2024

Keywords

  • AuNP
  • DNA metallization
  • DNA superstructures
  • immunotherapy
  • photothermal therapy

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