Nanoparticle-enabled terahertz imaging for cancer diagnosis

Seung Jae Oh; Jinyoung Kang; Inhee Maeng; Jin Suck Suh; Yong Min Huh; Seungjoo Haam; Joo Hiuk Son

doi:10.1364/OE.17.003469

Nanoparticle-enabled terahertz imaging for cancer diagnosis

Seung Jae Oh, Jinyoung Kang, Inhee Maeng, Jin Suck Suh, Yong Min Huh, Seungjoo Haam, Joo Hiuk Son

Department of Physics

Research output: Contribution to journal › Article › peer-review

166 Scopus citations

Abstract

This paper demonstrates the principle of the nanoparticle-contrast-agent- enabled terahertz imaging (CATHI) technique, which yields a dramatic sensitivity of the differential signal from cancer cells with nanoparticles. The terahertz (THz) reflection signal increased beam by 20% in the cancer cells with nanoparticles of gold nano-rods (GNRs) upon their irradiation with a infrared (IR) laser, due to the temperature rise of water in cancer cells by surface plasma ploritons. In the differential mode, the THz signal from the cancer cells with GNRs was 30 times higher than that from the cancer cells without GNRs. As the high sensitivity is achieved by the surface plasmon resonance through IR laser irradiation, the resolution of the CATHI technique can be as good as a few microns and THz endoscopy becomes more feasible.

Original language	English
Pages (from-to)	3469-3475
Number of pages	7
Journal	Optics Express
Volume	17
Issue number	5
DOIs	https://doi.org/10.1364/OE.17.003469
State	Published - 2 Mar 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1364/OE.17.003469

Cite this

@article{40ef9810fac74a2aac9569eee85f476f,

title = "Nanoparticle-enabled terahertz imaging for cancer diagnosis",

abstract = "This paper demonstrates the principle of the nanoparticle-contrast-agent- enabled terahertz imaging (CATHI) technique, which yields a dramatic sensitivity of the differential signal from cancer cells with nanoparticles. The terahertz (THz) reflection signal increased beam by 20% in the cancer cells with nanoparticles of gold nano-rods (GNRs) upon their irradiation with a infrared (IR) laser, due to the temperature rise of water in cancer cells by surface plasma ploritons. In the differential mode, the THz signal from the cancer cells with GNRs was 30 times higher than that from the cancer cells without GNRs. As the high sensitivity is achieved by the surface plasmon resonance through IR laser irradiation, the resolution of the CATHI technique can be as good as a few microns and THz endoscopy becomes more feasible.",

author = "Oh, {Seung Jae} and Jinyoung Kang and Inhee Maeng and Suh, {Jin Suck} and Huh, {Yong Min} and Seungjoo Haam and Son, {Joo Hiuk}",

year = "2009",

month = mar,

day = "2",

doi = "10.1364/OE.17.003469",

language = "English",

volume = "17",

pages = "3469--3475",

journal = "Optics Express",

issn = "1094-4087",

publisher = "Optica Publishing Group",

number = "5",

}

TY - JOUR

T1 - Nanoparticle-enabled terahertz imaging for cancer diagnosis

AU - Oh, Seung Jae

AU - Kang, Jinyoung

AU - Maeng, Inhee

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Haam, Seungjoo

AU - Son, Joo Hiuk

PY - 2009/3/2

Y1 - 2009/3/2

N2 - This paper demonstrates the principle of the nanoparticle-contrast-agent- enabled terahertz imaging (CATHI) technique, which yields a dramatic sensitivity of the differential signal from cancer cells with nanoparticles. The terahertz (THz) reflection signal increased beam by 20% in the cancer cells with nanoparticles of gold nano-rods (GNRs) upon their irradiation with a infrared (IR) laser, due to the temperature rise of water in cancer cells by surface plasma ploritons. In the differential mode, the THz signal from the cancer cells with GNRs was 30 times higher than that from the cancer cells without GNRs. As the high sensitivity is achieved by the surface plasmon resonance through IR laser irradiation, the resolution of the CATHI technique can be as good as a few microns and THz endoscopy becomes more feasible.

AB - This paper demonstrates the principle of the nanoparticle-contrast-agent- enabled terahertz imaging (CATHI) technique, which yields a dramatic sensitivity of the differential signal from cancer cells with nanoparticles. The terahertz (THz) reflection signal increased beam by 20% in the cancer cells with nanoparticles of gold nano-rods (GNRs) upon their irradiation with a infrared (IR) laser, due to the temperature rise of water in cancer cells by surface plasma ploritons. In the differential mode, the THz signal from the cancer cells with GNRs was 30 times higher than that from the cancer cells without GNRs. As the high sensitivity is achieved by the surface plasmon resonance through IR laser irradiation, the resolution of the CATHI technique can be as good as a few microns and THz endoscopy becomes more feasible.

UR - http://www.scopus.com/inward/record.url?scp=61549111300&partnerID=8YFLogxK

U2 - 10.1364/OE.17.003469

DO - 10.1364/OE.17.003469

M3 - Article

C2 - 19259185

AN - SCOPUS:61549111300

SN - 1094-4087

VL - 17

SP - 3469

EP - 3475

JO - Optics Express

JF - Optics Express

IS - 5

ER -

Nanoparticle-enabled terahertz imaging for cancer diagnosis

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this