Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010

Han Gil Cho; Jang Hoon Choi; Hyun Kyung Lee; Su Kyoung Mun; Jong Bok Lee; Eek Hoon Jho; Chun Kang; Young Hee Lim

doi:10.1007/s00705-013-1734-3

Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010

Han Gil Cho, Jang Hoon Choi, Hyun Kyung Lee, Su Kyoung Mun, Jong Bok Lee, Eek Hoon Jho, Chun Kang, Young Hee Lim

Department of Life Science

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

South Korean isolates of oseltamivir-resistant influenza viruses from 2005-2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008-2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed.

Original language	English
Pages (from-to)	2365-2370
Number of pages	6
Journal	Archives of Virology
Volume	158
Issue number	11
DOIs	https://doi.org/10.1007/s00705-013-1734-3
State	Published - Nov 2013

Keywords

Influenza viruses
Neuraminidase
Oseltamivir resistance

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10.1007/s00705-013-1734-3

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title = "Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010",

abstract = "South Korean isolates of oseltamivir-resistant influenza viruses from 2005-2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008-2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed.",

keywords = "Influenza viruses, Neuraminidase, Oseltamivir resistance",

author = "Cho, {Han Gil} and Choi, {Jang Hoon} and Lee, {Hyun Kyung} and Mun, {Su Kyoung} and Lee, {Jong Bok} and Jho, {Eek Hoon} and Chun Kang and Lim, {Young Hee}",

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doi = "10.1007/s00705-013-1734-3",

language = "English",

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AU - Cho, Han Gil

AU - Choi, Jang Hoon

AU - Lee, Hyun Kyung

AU - Mun, Su Kyoung

AU - Lee, Jong Bok

AU - Jho, Eek Hoon

AU - Kang, Chun

AU - Lim, Young Hee

PY - 2013/11

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N2 - South Korean isolates of oseltamivir-resistant influenza viruses from 2005-2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008-2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed.

AB - South Korean isolates of oseltamivir-resistant influenza viruses from 2005-2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008-2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed.

KW - Influenza viruses

KW - Neuraminidase

KW - Oseltamivir resistance

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JF - Archives of Virology

IS - 11

ER -

Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010

Abstract

Keywords

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