Photothermally Enhanced Molecular Delivery and Cellular Positioning on Patterned Plasmonic Interfaces

Tae Ho Kang, Seungki Lee, Jung A. Kwon, Jihwan Song, Inhee Choi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Photothermal conversion effect of plasmonic nanostructures is considered as a promising technique for cellular and molecular manipulations owing to controllability of local temperature. Therefore, this technique has been extensively applied to biological studies such as controlling cellular behavior, delivery of biologics, and biomolecular detection. Herein, we propose a novel method for directed cell positioning and photothermally modulated molecular delivery to the cells using patterned plasmonic interfaces. Plasmonic substrates with gold nanorods (GNRs) and cell adhesion molecules fabricated by microcontact printing are optimized for cellular positioning on designated patterns. Through the photothermal conversion effect of GNRs on the pattern, we further demonstrate on-demand, light-induced delivery of drug molecules to the target cells. We expect that this approach will provide a new way to study single cellular behaviors and enhance molecular delivery to the target cells.

Original languageEnglish
Pages (from-to)36420-36427
Number of pages8
JournalACS applied materials & interfaces
Issue number40
StatePublished - 9 Oct 2019


  • cell positioning
  • drug delivery
  • gold nanorods
  • microcontact printing
  • photothermal conversion
  • plasmonic interfaces


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