TY - GEN
T1 - Plasmon-based detection of toxicity biomarkers derived from microplastics-treated model animals
AU - Lee, Seungki
AU - Kang, Tae Ho
AU - Choi, Jinhee
AU - Choi, Inhee
N1 - Publisher Copyright:
© 2019 CBMS-0001.
PY - 2019
Y1 - 2019
N2 - Here, we present in-situ plasmon-based detection methods of toxicity biomarkers from microplastic (MPs)treated animals. Via Raman intensity mapping, the uptake of MPs in model animals is visualized without labels. Through RNAi library screening, two biomarkers including reactive oxygen species and transforming growth factor-β are determined for evaluating the toxicity of MPs. In addition, label-free sensitive detections of the toxicity biomarkers are achieved by plasmon resonance energy transfer and surface-enhanced Raman scattering. We believe that our suggested methods for visualizing MP species in organisms and detecting toxicity biomarkers would contribute to understand MP-induced toxicity as well as to develop environmental sensors.
AB - Here, we present in-situ plasmon-based detection methods of toxicity biomarkers from microplastic (MPs)treated animals. Via Raman intensity mapping, the uptake of MPs in model animals is visualized without labels. Through RNAi library screening, two biomarkers including reactive oxygen species and transforming growth factor-β are determined for evaluating the toxicity of MPs. In addition, label-free sensitive detections of the toxicity biomarkers are achieved by plasmon resonance energy transfer and surface-enhanced Raman scattering. We believe that our suggested methods for visualizing MP species in organisms and detecting toxicity biomarkers would contribute to understand MP-induced toxicity as well as to develop environmental sensors.
KW - Microplastic
KW - Plasmon resonance energy transfer
KW - Plasmon-based detection
KW - Reactive oxygen species
KW - Surface-enhanced Raman scattering
KW - Transforming growth factor-β
UR - http://www.scopus.com/inward/record.url?scp=85094955575&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85094955575
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 1411
EP - 1412
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PB - Chemical and Biological Microsystems Society
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -