Preparation and characterization of low molecular weight heparin by liquid phase plasma method

Do Jin Lee, Hangun Kim, Byung Hoon Kim, Young Kwon Park, Heon Lee, Sung Hoon Park, Sang Chul Jung

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

An liquid phase plasma process system was applied to the production of low molecular weight heparin. The molecular weight of produed heparin decreased with increasing liquid phase plasma treatment time. The abscission of the chemical bonds between the constituents of heparin by liquid phase plasma reaction did not alter the characteristics of heparin. Formation of any by-products due to side reaction was not observed. It is suggested that heparin was depolymerized by active oxygen radicals produced during the liquid phase plasma reaction.

Original languageEnglish
Pages (from-to)6210-6213
Number of pages4
JournalJournal of Nanoscience and Nanotechnology
Volume15
Issue number8
DOIs
StatePublished - 1 Jan 2015

Keywords

  • Depolymerization
  • Heparin
  • Liquid phase plasma
  • Molecular weight

Fingerprint

Dive into the research topics of 'Preparation and characterization of low molecular weight heparin by liquid phase plasma method'. Together they form a unique fingerprint.

Cite this