Abstract
An liquid phase plasma process system was applied to the production of low molecular weight heparin. The molecular weight of produed heparin decreased with increasing liquid phase plasma treatment time. The abscission of the chemical bonds between the constituents of heparin by liquid phase plasma reaction did not alter the characteristics of heparin. Formation of any by-products due to side reaction was not observed. It is suggested that heparin was depolymerized by active oxygen radicals produced during the liquid phase plasma reaction.
Original language | English |
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Pages (from-to) | 6210-6213 |
Number of pages | 4 |
Journal | Journal of Nanoscience and Nanotechnology |
Volume | 15 |
Issue number | 8 |
DOIs | |
State | Published - 1 Jan 2015 |
Keywords
- Depolymerization
- Heparin
- Liquid phase plasma
- Molecular weight