Preparation of low molecular weight heparin by microwave discharge electrodeless lamp/TiO2 photo-catalytic reaction

Do Jin Lee; Byung Hoon Kim; Sun Jae Kim; Jung Sik Kim; Heon Lee; Sang Chul Jung

doi:10.1166/jnn.2015.8377

Preparation of low molecular weight heparin by microwave discharge electrodeless lamp/TiO₂ photo-catalytic reaction

Do Jin Lee, Byung Hoon Kim, Sun Jae Kim, Jung Sik Kim, Heon Lee, Sang Chul Jung

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

An MDEL/TiO₂ photo-catalyst hybrid system was applied, for the first time, for the production of low molecular weight heparin. The molecular weight of produed heparin decreased with increasing microwave intensity and treatment time. The abscission of the chemical bonds between the constituents of heparin by photo-catalytic reaction did not alter the characteristics of heparin. Formation of by-products due to side reaction was not observed. It is suggested that heparin was depolymerized by active oxygen radicals produced during the MDEL/TiO₂ photo-chemical reaction.

Original language	English
Pages (from-to)	680-683
Number of pages	4
Journal	Journal of Nanoscience and Nanotechnology
Volume	15
Issue number	1
DOIs	https://doi.org/10.1166/jnn.2015.8377
State	Published - 1 Jan 2015

Keywords

Depolymerization
Heparin
Microwave
TiO

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abstract = "An MDEL/TiO2 photo-catalyst hybrid system was applied, for the first time, for the production of low molecular weight heparin. The molecular weight of produed heparin decreased with increasing microwave intensity and treatment time. The abscission of the chemical bonds between the constituents of heparin by photo-catalytic reaction did not alter the characteristics of heparin. Formation of by-products due to side reaction was not observed. It is suggested that heparin was depolymerized by active oxygen radicals produced during the MDEL/TiO2 photo-chemical reaction.",

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AU - Lee, Do Jin

AU - Kim, Byung Hoon

AU - Kim, Sun Jae

AU - Kim, Jung Sik

AU - Lee, Heon

AU - Jung, Sang Chul

PY - 2015/1/1

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N2 - An MDEL/TiO2 photo-catalyst hybrid system was applied, for the first time, for the production of low molecular weight heparin. The molecular weight of produed heparin decreased with increasing microwave intensity and treatment time. The abscission of the chemical bonds between the constituents of heparin by photo-catalytic reaction did not alter the characteristics of heparin. Formation of by-products due to side reaction was not observed. It is suggested that heparin was depolymerized by active oxygen radicals produced during the MDEL/TiO2 photo-chemical reaction.

AB - An MDEL/TiO2 photo-catalyst hybrid system was applied, for the first time, for the production of low molecular weight heparin. The molecular weight of produed heparin decreased with increasing microwave intensity and treatment time. The abscission of the chemical bonds between the constituents of heparin by photo-catalytic reaction did not alter the characteristics of heparin. Formation of by-products due to side reaction was not observed. It is suggested that heparin was depolymerized by active oxygen radicals produced during the MDEL/TiO2 photo-chemical reaction.

KW - Depolymerization

KW - Heparin

KW - Microwave

KW - TiO

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JF - Journal of Nanoscience and Nanotechnology

IS - 1

ER -

Preparation of low molecular weight heparin by microwave discharge electrodeless lamp/TiO₂ photo-catalytic reaction

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Keywords

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