Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient

Rami Lee, Ji Hun Kim, Hongik Hwang, Hyewhon Rhim, Sung Hee Hwang, Ik Hyun Cho, Do Geun Kim, Hyoung Chun Kim, Seung Yeol Nah

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Ginseng is one of the traditional herbal medicines for tonic. Gintonin is a new material derived from white/red ginseng and its lysophosphatidic acids (LPAs) play as a ligand for G protein-coupled LPA receptors. Korean red ginseng marc (KRGM) is a by-product after the KRG processes. We developed a low-cost/high-efficiency method for KRGM gintonin production. We further studied the KRGM gintonin-mediated anti-skin aging effects under UVB exposure using human dermal fibroblasts (HDFs). KRGM gintonin yield is about 8%. KRGM gintonin contains a high amount of LPA C18:2, lysophosphatidylcholine (LPC), and phosphatidylcholine (PC), which is similar to white ginseng gintonin. KRGM gintonin induced [Ca2+]i transient via LPA1/3 receptors and increased cell viability/proliferation under UVB exposure. The underlying mechanisms of these results are associated with the antioxidant action of KRGM gintonin. KRGM gintonin attenuated UVB-induced cell senescence by inhibiting cellular β-galactosidase overexpression and facilitated wound healing. These results indicate that KRGM can be a novel bioresource of KRGM gintonin, which can be industrially utilized as new material for skin nutrition and/or skin healthcare.

Original languageEnglish
Article number2574
Issue number11
StatePublished - Jun 2023


  • Korean red ginseng marc
  • LPA receptors
  • cosmetics
  • gintonin
  • skin damage


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