Protein structure-based design of anti-protozoal drugs

Christophe L.M.J. Verlinde, Jerome C. Bressi, Jungwoo Choe, Stephen Suresh, Frederick S. Buckner, Wesley C. Van Voorhis, Paul A.M. Michels, Michael H. Gelb, Wim G.J. Hol

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The repertory of drugs to fight protozoal diseases such as malaria, Chagas' disease, leishmaniasis, and African trypanosomiasis is woefully inadequate. Now, genome sequencing and structural genomics projects are quickly elucidating new drug targets, providing incredible opportunities for medicinal chemists. Here, we illustrate the power of structure-based drug design in this process by our efforts to selectively block trypanosomal glycolysis.

Original languageEnglish
Pages (from-to)843-848
Number of pages6
JournalJournal of the Brazilian Chemical Society
Issue number6
StatePublished - 2002


  • African trypanosomiasis
  • Chagas' disease
  • Drug design
  • Leishmaniasis
  • Malaria


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