Protein structure-based design of anti-protozoal drugs

Christophe L.M.J. Verlinde; Jerome C. Bressi; Jungwoo Choe; Stephen Suresh; Frederick S. Buckner; Wesley C. Van Voorhis; Paul A.M. Michels; Michael H. Gelb; Wim G.J. Hol

doi:10.1590/s0103-50532002000600018

Protein structure-based design of anti-protozoal drugs

Christophe L.M.J. Verlinde
, Jerome C. Bressi
, Jungwoo Choe
, Stephen Suresh
, Frederick S. Buckner
, Wesley C. Van Voorhis
, Paul A.M. Michels
, Michael H. Gelb
, Wim G.J. Hol

Department of Life Science

University of Washington
Université catholique de Louvain

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The repertory of drugs to fight protozoal diseases such as malaria, Chagas' disease, leishmaniasis, and African trypanosomiasis is woefully inadequate. Now, genome sequencing and structural genomics projects are quickly elucidating new drug targets, providing incredible opportunities for medicinal chemists. Here, we illustrate the power of structure-based drug design in this process by our efforts to selectively block trypanosomal glycolysis.

Original language	English
Pages (from-to)	843-848
Number of pages	6
Journal	Journal of the Brazilian Chemical Society
Volume	13
Issue number	6
DOIs	https://doi.org/10.1590/s0103-50532002000600018
State	Published - 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

African trypanosomiasis
Chagas' disease
Drug design
GAPDH
Leishmaniasis
Malaria

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10.1590/s0103-50532002000600018

Cite this

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title = "Protein structure-based design of anti-protozoal drugs",

abstract = "The repertory of drugs to fight protozoal diseases such as malaria, Chagas' disease, leishmaniasis, and African trypanosomiasis is woefully inadequate. Now, genome sequencing and structural genomics projects are quickly elucidating new drug targets, providing incredible opportunities for medicinal chemists. Here, we illustrate the power of structure-based drug design in this process by our efforts to selectively block trypanosomal glycolysis.",

keywords = "African trypanosomiasis, Chagas' disease, Drug design, GAPDH, Leishmaniasis, Malaria",

author = "Verlinde, \{Christophe L.M.J.\} and Bressi, \{Jerome C.\} and Jungwoo Choe and Stephen Suresh and Buckner, \{Frederick S.\} and \{Van Voorhis\}, \{Wesley C.\} and Michels, \{Paul A.M.\} and Gelb, \{Michael H.\} and Hol, \{Wim G.J.\}",

year = "2002",

doi = "10.1590/s0103-50532002000600018",

language = "English",

volume = "13",

pages = "843--848",

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TY - JOUR

T1 - Protein structure-based design of anti-protozoal drugs

AU - Verlinde, Christophe L.M.J.

AU - Bressi, Jerome C.

AU - Choe, Jungwoo

AU - Suresh, Stephen

AU - Buckner, Frederick S.

AU - Van Voorhis, Wesley C.

AU - Michels, Paul A.M.

AU - Gelb, Michael H.

AU - Hol, Wim G.J.

PY - 2002

Y1 - 2002

N2 - The repertory of drugs to fight protozoal diseases such as malaria, Chagas' disease, leishmaniasis, and African trypanosomiasis is woefully inadequate. Now, genome sequencing and structural genomics projects are quickly elucidating new drug targets, providing incredible opportunities for medicinal chemists. Here, we illustrate the power of structure-based drug design in this process by our efforts to selectively block trypanosomal glycolysis.

AB - The repertory of drugs to fight protozoal diseases such as malaria, Chagas' disease, leishmaniasis, and African trypanosomiasis is woefully inadequate. Now, genome sequencing and structural genomics projects are quickly elucidating new drug targets, providing incredible opportunities for medicinal chemists. Here, we illustrate the power of structure-based drug design in this process by our efforts to selectively block trypanosomal glycolysis.

KW - African trypanosomiasis

KW - Chagas' disease

KW - Drug design

KW - GAPDH

KW - Leishmaniasis

KW - Malaria

UR - https://www.scopus.com/pages/publications/0036989015

U2 - 10.1590/s0103-50532002000600018

DO - 10.1590/s0103-50532002000600018

M3 - Article

AN - SCOPUS:0036989015

SN - 0103-5053

VL - 13

SP - 843

EP - 848

JO - Journal of the Brazilian Chemical Society

JF - Journal of the Brazilian Chemical Society

IS - 6

ER -

Protein structure-based design of anti-protozoal drugs

Abstract

UN SDGs

Keywords

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