Regulation of Hippo signaling by metabolic pathways in cancer

Ukjin Lee, Eun Young Cho, Eek Hoon Jho

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Hippo signaling is known to maintain balance between cell proliferation and apoptosis via tight regulation of factors, such as metabolic cues, cell-cell contact, and mechanical cues. Cells directly recognize glucose, lipids, and other metabolic cues and integrate multiple signaling pathways, including Hippo signaling, to adjust their proliferation and apoptosis depending on nutrient conditions. Therefore, the dysregulation of the Hippo signaling pathway can promote tumor initiation and progression. Alteration in metabolic cues is considered a major factor affecting the risk of cancer formation and progression. It has recently been shown that the dysregulation of the Hippo signaling pathway, through diverse routes activated by metabolic cues, can lead to cancer with a poor prognosis. In addition, unique crosstalk between metabolic pathways and Hippo signaling pathways can inhibit the effect of anticancer drugs and promote drug resistance. In this review, we describe an integrated perspective of the relationship between the Hippo signaling pathway and metabolic signals in the context of cancer. We also characterize the mechanisms involved in changes in metabolism that are linked to the Hippo signaling pathway in the cancer microenvironment and propose several novel targets for anticancer drug treatment.

Original languageEnglish
Article number119201
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Issue number4
StatePublished - Apr 2022


  • Drug resistance
  • Glucose
  • Hippo signaling pathway
  • Lipids
  • Metabolism


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