Relation of serum uric acid to an exaggerated systolic blood pressure response to exercise testing in men with normotension

Sae Young Jae, Kanokwan Bunsawat, Yoon Ho Choi, Yeon Soo Kim, Rhian M. Touyz, Jeong Bae Park, Barry A. Franklin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The authors investigated the hypothesis that high serum uric acid concentrations may be related to an exaggerated systolic blood pressure (SBP) response to maximal exercise testing in men with normotension, independent of potential confounding variables. In 4640 healthy men with normotension who underwent maximal treadmill exercise testing and fasting blood chemistry studies, including serum uric acid concentrations, an exaggerated SBP response, defined as SBP ≥ 210 mm Hg, was detected in 152 men (3.3%). After adjusting for potential confounders, participants in the highest quartile of serum uric acid (>6.6 mg/dL) had a higher odds ratio of demonstrating an exaggerated SBP to maximal exercise (odds ratio, 2.19; 95% confidence interval, 1.24–3.86) compared with participants in the lowest quartile of serum uric acid (<5.1 mg/dL). High serum uric acid concentrations are associated with an exaggerated SBP response to maximal exercise testing in men with normotension, independent of established coronary risk factors.

Original languageEnglish
Pages (from-to)551-556
Number of pages6
JournalJournal of Clinical Hypertension
Volume20
Issue number3
DOIs
StatePublished - Mar 2018

Keywords

  • exaggerated systolic blood pressure response
  • exercise testing
  • uric acid

Fingerprint

Dive into the research topics of 'Relation of serum uric acid to an exaggerated systolic blood pressure response to exercise testing in men with normotension'. Together they form a unique fingerprint.

Cite this