ROC estimation from clustered data with an application to liver cancer data

Joungyoun Kim, Sung Cheol Yun, Johan Lim, Moo Song Lee, Won Son, Do Hwan Park

Research output: Contribution to journalArticlepeer-review


In this article, we propose a regression model to compare the performances of different diagnostic methods having clustered ordinal test outcomes. The proposed model treats ordinal test outcomes (an ordinal categorical variable) as grouped-survival time data and uses random effects to explain correlation among outcomes from the same cluster. To compare different diagnostic methods, we introduce a set of covariates indicating diagnostic methods and compare their coefficients. We find that the proposed model defines a Lehmann family and can also introduce a location-scale family of a receiver operating characteristic (ROC) curve. The proposed model can easily be estimated using standard statistical software such as SAS and SPSS. We illustrate its practical usefulness by applying it to testing different magnetic resonance imaging (MRI) methods to detect abnormal lesions in a liver.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalCancer Informatics
StatePublished - 22 Dec 2016


  • Clustered data
  • Grouped-time survival
  • Lehmann family
  • Ordinal outcomes
  • Random effects
  • Receiver operating characteristic (ROC) curve


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